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• (1993)
The Cytochrome P-450 class of monoxygenases carry out a wide variety of hydroxylation, epoxidation and heteroatom oxidation reactions. The cytochrome P-450cam enzyme from P. putida has been widely studied as a model for ...

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• (1972)

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• (2013-02-03)
For the past few decades, biosensors have been developed at a steady pace and played a crucial role in medical practices and many other biomedical applications. Upon performing a survey of desirable sensor properties such ...

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• (2013-05-28)
Within the past decade, there has been abounding scientific evidences supporting the notion that mechanical forces are crucial in regulating the physiologic functions of cells and tissues. The importance of engineering ...

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• (2006-10)
Fluorescence single molecule localization has become a powerful tool for investigating problems in biological physics. However, there are numerous limitations on the types of measurements that can be made with typical ...

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• (1989)
Bacterium Rhodopseudomonas viridis has four c-type cytochromes integrated to a single protein subunit of the reaction center complex. Two of them are high redox midpoint potential hemes (cyt-c559; Em = 380 mV and cyt-c556; ...

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• (1991)
Chromatin, the building material of chromosomes, is folded and unfolded by several levels, providing a physical basis of coordinated DNA functions in eukaryotic cells. Chromatin folding is started with a linear long string ...

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• (2009)
C-type lectins are a prominent class of pathogen recognition receptors in the innate immune system. The three pathogen recognition lectins studied in this thesis are the mannose binding protein (MBP), the dendritic ...

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• (2010-05-19)
Single-walled carbon nanotubes (SWNT) have unique photo-physical properties which, through the work in this dissertation, are investigated and harnessed to produce optical sensors with unique capabilities. Early studies ...

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• (2007)
Precise positioning of axons and dendrites in the CNS holds the key to establishing neural networks. To achieve this, each subcellular compartment in differentiating neurons must translate cues from surrounding tissues ...

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• (2010-05-20)
Promoting bio-based products is one oft-proposed solution to reduce GHG emissions because the feedstocks capture carbon, offsetting at least partially the carbon discharges resulting from use of the products. However, ...

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• (1970)

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• (2013-08-22)
Amplifiers for biomedical applications have been a subject of study for more than a century. However, it was not until this last decade that amplifiers that conform to the skin mechanics were introduced. The introduction ...

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• (1965)

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• (1998)
Next, it was desired to obtain structural information on in vivo GPI anchor intermediates. To address this issue, I exploited the fact that at non-permissive temperature, the yeast dpm1--6 mutant accumulates GlcNH2-(acy ...

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• (2015-10-29)
Natural products have played prominent roles in science and medicine due to their diverse chemical scaffolds and biological activities. Ribosomally synthesized and post-translationally modified peptides (RiPPs) have recently ...

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• (2014-09-16)
The emergence of antibiotic-resistant bacterial strains is a growing concern as antimicrobial drug discovery is not proceeding at the same pace as the growth of resistance. Genome sequencing techniques have advanced in the ...

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• (2012-02-01)
One of the greatest sources of biologically active compounds is natural products. Often these compounds serve as platforms for the design and development of novel drugs and therapeutics. The overwhelming amount of genomic ...

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• (2004)
The myelin sheath is a specialized membrane in the nervous system that facilitates the transmission of nerve impulses in a fast and efficient manner. Steroids hormones can be synthesized de novo in the nervous system. The ...

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• (1990)
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. ($U$-$\sp{14}$C) -L-Tyrosine, ($U$-$\sp{14}$C) -L-3-bromotyrosine, and ($U$-$\sp{14}$) -3,5-dibromotyrosine ...

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