Browse by Subject "aptamer"
Now showing items 1-5 of 5
Applications of functional nucleic acids in imaging, sensing and drug delivery and investigations of DNAzyme-metal interactions (2011-05-25)Functional nucleic acids (FNA), including nucleic acids catalysts (ribozymes and DNAzymes) and ligands (aptamers), have been discovered in nature or isolated in a laboratory through a process called in vitro selection. ...
(2010-08-31)The aim of my Ph. D. thesis is to generalize a method for targeted anti-cancer drug delivery. Hydrophilic polymer-drug conjugates involve complicated synthesis; drug-encapsulated polymeric nanoparticles limit the loading ...
(2012-09-18)Normal miRNA production is essential for regulating protein expression and cellular fate. Misregulation of miRNA production is emerging as a key factor in the development of many disease states, including most forms cancer. ...
(2011-05-25)In 1990 the Szostak and Gold groups independently discovered that short pieces of RNA can bind to small molecule or biological targets. In 1994 the Joyce group showed that DNA, long thought to be solely for information ...
I. In vitro selection of aptamers for perchlorate and melamine II. Towards crystallization of DNAzymes III. A highly selective lead sensor based on a classic lead DNAzyme (2013-02-03)Nature has given nucleic acids irreplaceable roles for all living creatures. It plays important roles in genetic information storage and transfer, as well as regulating various aspects of biology. The discovery of in vitro ...