Browse by Subject "mechanotransduction"
Now showing items 1-7 of 7
(2013-05-28)Within the past decade, there has been abounding scientific evidences supporting the notion that mechanical forces are crucial in regulating the physiologic functions of cells and tissues. The importance of engineering ...
(2010-01-06)Cadherins mediate Ca2+ dependent cell-cell junction in all animal tissues. Tight regulation of cadherin adhesion plays critical roles in diverse biological processes. Differential binding between cadherin subtypes is widely ...
(2010-05-18)The role of soluble factors in determining embryonic stem cell fate has been well studied. A growing body of research indicates mechanical cues are equally important to chemical signals in eliciting cellular response, ...
(2015-12-03)Cadherins and integrin receptors form crucial extracellular adhesive connections with, respectively, adjacent cells and the extracellular matrix, and transduce mechanical signals across cell membranes. The role of adhesive ...
Investigation of a role for the α7 integrin as a mechanotransducer of hypertrophic signaling in skeletal muscle (2013-02-03)The α7β1 integrin is a transmembrane protein in skeletal muscle which serves as a focal adhesion at costameres of skeletal muscle, providing a critical link between the actin cytoskeleton inside the cell with laminin in ...
(2015-01-21)Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical ...
(2010-01-06)It is well-known that mechanical forces are crucial in regulating functions of every tissue and organ in a human body. However, it remains unclear how mechanical forces are transduced into biochemical activities and ...