Browse by Subject "non-viral gene delivery"
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The effects of PVP(FE(III)) catalyst and polymer molecular weight on gene delivery via biodegradable crosslinked polyethylenimine (2011-01-21)Human gene therapy has faced many setbacks due to the immunogenicity and oncogenity of viruses. Safe and efficient alternative gene delivery vehicles are needed to implement gene therapy in clinical practice. Polymeric ...
Quo vadis: quantitative evaluation of intracellular kinetics of siRNA delivered by poly-and-lipoplexes (2015-12-03)Small interfering RNA (siRNA), when delivered to cells, is able to elicit a potent post transcriptional gene silencing with enormous therapeutic potential. It has been demonstrated that siRNA is able to tackle a wide range ...