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Title:PHASE-CONTROLLED DUAL-COMB COHERENT ANTI-STOKES RAMAN SPECTROSCOPIC IMAGING
Author(s):Wei, Haoyun
Contributor(s):Li, Yan; Wu, Tao; Chen, Kun
Subject(s):Mini-symposium: Frequency-Comb Spectroscopy
Abstract:Coherent Raman microscopy can intrinsically enable label-free imaging by measuring vibrational spectra of biomolecules. Nevertheless, trade-off between high chemical-specificity and high imaging-speed currently exists in transition from spectroscopy to spectroscopic imaging when capturing dynamics in complex living systems. Here, we present a dual-comb scheme to substantially beat this trade-off and facilitate high-resolution broadband coherent anti-Stokes Raman spectroscopic imaging by combining dual-comb asynchronous optical scanning and phase-controlled spectral focusing excitation. A rapid measurement of vibrational micro-spectroscopy on sub-microsecond scale over a spectral span ~700 \wn with solid signal-to-noise ratio provides access to well-resolved molecular signatures within the fingerprint region. We demonstrate this high-performance spectroscopic imaging for spatially inhomogeneous distributions of chemical substances. This technique offers an unprecedented route for broadband CARS imaging with hundreds of kHz spectroscopic refresh rate using available 1-GHz oscillators.
Issue Date:06/19/18
Publisher:International Symposium on Molecular Spectroscopy
Citation Info:APS
Genre:Conference Paper / Presentation
Type:Text
Language:English
URI:http://hdl.handle.net/2142/100618
DOI:10.15278/isms.2018.TA08
Other Identifier(s):TA08
Date Available in IDEALS:2018-08-17
2018-12-12


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