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Title:THE ROTATIONAL STUDY OF DOPAC, A NEURAL METABOLITE
Author(s):Alonso, Elena R.
Contributor(s):Alonso, José L.; Cabezas, Carlos; Kolesniková, Lucie; León, Iker
Subject(s):Conformers and isomers
Abstract:DOPAC (3,4-Dihydroxyphenylacetic acid) is an intermediate neural metabolite in the cycle of catecholamines,\footnote{ C. Cabezas, I. Peña, J. C. López and J. L. Alonso, Seven conformers of neutral dopamine revealed in the gas phase, J. Phys. Chem. Lett., 2013, 4, 486–490 and references therein.} concretely in the metabolic reaction of dopamine (DA) to produce homovanillic acid (HVA), a substance that being present in urine in a large quantity, is indicative of health problems. In this work, we present a rotational study to explore the conformational preferences of DOPAC. It has been brought into gas phase avoiding decomposition by laser ablation LA of the solid sample, and the conformers present in the supersonic expansion have been probed by CP-FTMW spectroscopy.\footnote{I. Peña, S. Mata, A. Martín, C. Cabezas, A. M. Daly and J. L. Alonso, Conformations of D-xylose: the pivotal role of the intramolecular hydrogen-bonding., Phys. Chem. Chem. Phys., 2013, 15, 18243–8.} As we will show, several conformers have been detected and characterized. All the data obtained is presented in this communication.
Issue Date:06/20/18
Publisher:International Symposium on Molecular Spectroscopy
Citation Info:APS
Genre:Conference Paper / Presentation
Type:Text
Language:English
URI:http://hdl.handle.net/2142/100665
DOI:10.15278/isms.2018.WJ01
Other Identifier(s):WJ01
Date Available in IDEALS:2018-08-17
2018-12-12


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