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Title:Glutathione utilization in lactobacillus fermentum CECT 5716
Author(s):Surya, Agustian
Advisor(s):Miller, Michael J.
Department / Program:Food Science & Human Nutrition
Discipline:Food Science & Human Nutrition
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):Glutathione, Lactobacillus fermentum, Oxidative stress, Metal Stress, Lactic Acid Bacteria
Abstract:Glutathione, a tripeptide antioxidant, has recently been shown to be either utilized or synthesized by gram-positive bacteria, such as Lactic Acid Bacteria. Glutathione plays an important role in countering environmental stress, such as oxidative stress. In this study, cellular activity regarding glutathione in Lactobacillus fermentum CECT 5716 is characterized. We demonstrate that L. fermentum CECT 5716 has a better survival rate in the presence of glutathione under both oxidative and metal stress. As L. fermentum CECT 5716 does not possess the ability to synthesize glutathione, it shows the ability to uptake both reduced and oxidized glutathione from the environment, regenerate reduced glutathione from oxidized glutathione, and perform secretion of glutathione to the environment.
Issue Date:2018-07-17
Type:Thesis
URI:http://hdl.handle.net/2142/101717
Rights Information:Copyright 2018 Agustian Surya
Date Available in IDEALS:2018-09-27
Date Deposited:2018-08


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