Files in this item



application/pdfLEE-THESIS-2018.pdf (2MB)
(no description provided)PDF


Title:Effects of a hyperimmunized egg product on voluntary physical activity levels, serum inflammatory markers, and owner perception of joint pain of dogs with osteoarthritis
Author(s):Lee, Anne H.
Advisor(s):Swanson, Kelly S.
Contributor(s):Fahey, Jr., George; de Godoy, Maria R. C.
Department / Program:Animal Sciences
Discipline:Animal Sciences
Degree Granting Institution:University of Illinois at Urbana-Champaign
Hyperimmune Egg
Abstract:Osteoarthritis (OA) affects about 20% of adult dogs in North America, resulting in reduced range of motion, difficulty climbing and jumping, reduced physical activity, and lower quality of life. A double-blind, placebo-controlled study was conducted to evaluate the effects of short-term supplementation of hyperimmunized egg (HIE) on voluntary activity levels, serum chemistry and inflammatory markers, and owner perception of joint pain in dogs diagnosed with OA. Eighty-two client-owned dogs with clinical signs and veterinary diagnosis of OA were enrolled and sixty-nine dogs (mean age = 8.0 ± 3.4 yr; mean BW = 32.3 ± 11.3 kg) completed a 49-d study composed of a 7-d baseline period followed by a 42-d treatment period. The Institutional Animal Care and Use Committee at the University of Illinois approved all procedures, and owner consent was received prior to experimentation. Enrolled dogs were randomly assigned to one of three treatment groups: treatment 1 (placebo; 0 g HIE/chew; n = 22), treatment 2 (2 g HIE/chew; n = 24), and treatment 3 (3 g HIE/chew; n = 23). Assigned treatments were given in the form of soft-chew treats, with dogs receiving one treat for every 9.07 kg BW daily. A physical examination, radiographs, and blood sample collection were performed at the time of enrollment (d -7) and dogs were sent home with the assigned treatment and a HeyRex (Wellington, New Zealand) activity monitor to wear continuously for 49 d. In addition, owners were required to complete canine brief pain inventory (CBPI) and Liverpool osteoarthritis in dogs (LOAD) survey questionnaires at baseline (d -7), and on d 14, 28, and 42 of the study. On the last day of the study (d 42), another blood sample was collected. Blood samples were used for serum chemistry and inflammatory marker measurements. Statistical analysis was conducted using SAS® (version 9.3; SAS Institute, Inc., Cary, NC) using the Mixed Models procedure with a repeated measures design. Data were reported as means ± SEM with statistical significance set at P<0.05 with P<0.10 considered a trend. Results of CBPI survey data showed some significant time effects, with average pain; pain as of right now; interference with the ability to rise from a lying position; interference with the ability to walk; interference with the ability to climb; pain severity score; and pain interference score decreasing (P<0.05) over time. CBPI scores for pain at its least and interference with general activity tended to decrease (P<0.10) over time. Blood C-reactive protein concentrations tended to be greater (P<0.10) in dogs fed the low-dose HIE compared to those fed the placebo or high-dose HIE. Voluntary physical activity was different due to treatment and time. Weekly, weekday, and weekend activity data were greater (P<0.05) in dogs fed the low-dose HIE than for dogs fed placebo or high-dose HIE. Baseline activity data were highest in this group, however, so these differences did not appear to be due to HIE treatment. Weekly, weekday, and weekend activity decreased (P<0.05) over time. In conclusion, results of the current study did not show significant changes in physical activity levels, blood markers, or owner perception of joint pain after consuming a HIE product. Although HIE products of a different source, of higher quality, or of higher dosage may be of interest for future research, the results of the current study do not support the use of HIE for alleviating clinical signs associated with canine OA.
Issue Date:2018-11-26
Rights Information:Copyright 2018 Anne Lee
Date Available in IDEALS:2019-02-06
Date Deposited:2018-12

This item appears in the following Collection(s)

Item Statistics