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Title:Photonic crystal enhanced light emitters and their use in improving cancer screening and disease progression monitoring
Author(s):Race, Caitlin M.
Director of Research:Cunningham, Brian T.
Doctoral Committee Chair(s):Cunningham, Brian T.
Doctoral Committee Member(s):Eden, James G.; Gruev, Viktor; Smith, Andrew
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Photonic crystals
Quantum dots
Metamaterials
Biosensing
Photonic hypercrystals
PCEF
Photonic crystal enhanced fluorescence
Abstract:Screening for and monitoring the progression of cancer remains a complex task in medicine today, further complicated by the variety of both cancer types and treatments. Each patient's response to treatments and cancers is unique, calling for a personalized approach to healthcare. Early detection and correct treatment of cancer are critical for controlling disease progression and improving patient outcomes. This dissertation describes a photonic crystal-based detection and analysis system to improve cancer screening and treatment by increasing sensitivity to low concentrations of cancer biomarkers. There are two main methods of increasing sensitivity: automating detection and analysis to reduce time and user error, and improving coupling efficiency by optimizing photonic crystal design parameters. I address both these methods in this work: the former by increasing sensitivity in the screening for oropharyngeal cancer, and the latter in the design of two new photonic crystals. The first of these photonic crystals is designed for enhanced excitation of multi-colored quantum dots, instead of traditional fluorescent dyes, for the investigation of multiplexed treatment progression monitoring of prostate cancer. The second of these photonic crystals is a design for metamaterial-based photonic crystals that improves coupling efficiency and offers additional design flexibility. This new photonic crystal is interchangeable with the photonic crystal designed to enhance quantum dots but can also be used in a standard microscope setup. The objective is to retain high enhancement while improving coupling to the photonic crystal resonance to increase fluorescent output. This work presents my efforts toward the development of technologies that will enable low-cost, portable screening and disease monitoring to improve outcomes for patients around the world. The ultimate goal is to improve patient access to vital healthcare practices while keeping expenses low and standard of detection high.
Issue Date:2018-11-12
Type:Text
URI:http://hdl.handle.net/2142/102908
Rights Information:© 2018 Caitlin M. Race
Date Available in IDEALS:2019-02-08
Date Deposited:2018-12


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