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Title:Unraveling cell nucleus structure
Author(s):Liu, Wenjie
Subject(s):Bioengineering
Abstract:Cell nucleus stores our genetic information within DNA. It is estimated that about 3.2 billion bases of DNA (around 1 m in length) reside in the nucleus, which is packaged as chromatins. The local structure of chromatin lies the blueprint that dictates everything a cell does. Such small and fascinating structure was not able to be fully resolved under microscope several years ago. With recent advance in super-resolution imaging, this becomes possible. My research looks at those tiny structures at single cell level beyond the diffraction limit. I investigated the dynamic of nucleus structure on cell function with environmental pollution. We discovered that Perfluorooctanoic acid (coating material for non-stick pot) could change the heterochromatin structure, resulting in cancerous cell fate.
Issue Date:2019
Type:Text
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URI:http://hdl.handle.net/2142/103707
Rights Information:Copyright 2019 Wenjie Liu
Date Available in IDEALS:2019-05-03


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