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Title:Assessing the Effects of Environmentally Relevant Concentrations of Antidepressant Mixtures to Fathead Minnows Exposed Over a Full Life Cycle
Author(s):Parrott, Joanne; Metcalfe, Chris
Subject(s):PPCPs
pharmaceuticals
fish
Abstract:Fathead minnow were exposed over a full lifecycle to a mixture of five antidepressants at 1x the concentrations found in an Ontario MWWE and at 10x those. Measured concentrations of venlafaxine, citalopram, fluoxetine, sertraline, and bupropion were 2,300, 160, 110, 7, and 0 ng/L, respectively, in the 1x Mix. During the 168 d exposure, no significant changes were observed in survival. When male fish from the exposed treatments reached maturity, their weights were increased (10x Mix) and secondary sex characteristics were enhanced (1x Mix) compared to control males. There were no differences relative to controls in condition factor, gonads or liver sizes. Exposed fish produced similar numbers of eggs as control fish. There were no changes in nest-defense behaviors of male minnows. Egg quality, % fertilization, and % hatching in F1 fry were unaffected. Eggs hatched 0.5 d earlier, deformities in fry were 50% lower, and there were transient decreases in length of 8 d old F1 larvae from the 10x Mix in comparison to controls. Overall, exposure to the antidepressant mixture at environmentally relevant concentrations caused no adverse effects. Exposure to the 10x Mix increased the weight of adult male minnows and caused subtle effects in F1 offspring.
Issue Date:2019-05-21
Series/Report:2019 Emerging Contaminants in the Environment Conference (ECEC19)
Genre:Conference Paper / Presentation
Type:Text
Language:English
URI:http://hdl.handle.net/2142/103972
Date Available in IDEALS:2019-05-31


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