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Title:STUDY OF ELEMENTAL AND MOLECULAR EVIDENCES IN DRUGS USING LIBS
Author(s):Tiwari, P. K.
Contributor(s):Rai, A. K.
Subject(s):Spectroscopy as an analytical tool
Abstract:Laser Induced Breakdown Spectroscopy (LIBS) spectra of some WHO listed essential pharmaceutical drugs have been recorded in air and argon atmosphere. The spectral signatures of characteristic molecular emission of the CN violet band system and C2 Swan band system along with the atomic and ionic lines of various elements are observed in the LIBS spectra of the drug samples. We have measured the intensity of these molecular bands. With the help of the intensities of these bands, an attempt has been made to correlate the CN violet and C2 swan band with the chemical structure of the molecule present in the drugs. The essential drugs of different brands have been taken for the LIBS analysis. PCA (a multivariate method) has also been applied on the LIBS dataset for the discrimination purpose of the drugs which have a similar composition. In addition to this, for the confirmation of the molecules present in the drug, complementary molecular spectroscopic techniques, called Raman and FT-IR spectroscopy, have been applied to find out the molecular spectra of these drug samples. With the implementation of the above approach, it is established that LIBS techniques may be used as an online drugs analysis technique in pharmaceutical industries.
Issue Date:2019-06-20
Publisher:International Symposium on Molecular Spectroscopy
Genre:Conference Paper / Presentation
Type:Text
Language:English
URI:http://hdl.handle.net/2142/104264
DOI:10.15278/isms.2019.RL02
Rights Information:Copyright 2019 P. K. Tiwari
Date Available in IDEALS:2019-07-15
2020-01-25


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