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Title:Epigenetic mechanisms of resilience to psychopathology following trauma exposure
Author(s):Bucknor, Brianna
Advisor(s):Hankin, Benjamin L.
Department / Program:Psychology
Discipline:Psychology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:M.S.
Genre:Thesis
Subject(s):PTSD
trauma
resilience
psychopathology
epigenetics
Abstract:There is a dearth of research examining epigenetic modifications associated with resilience to psychopathology after trauma exposure. This study sought to investigate resilience-associated methylation differences in 51 glucocorticoid receptor regulatory network (GRRN) genes which have been previously associated with various forms of psychopathology. Multiple linear regressions were performed on each of the CpG sites associated with the 51 GRRN genes with resiliency as the predictor and DNA methylation as the outcome in a sample of 171 Detroit residents age 20-89 (M = 54.00, SD =14.14, 63.2% female). Resilience was significantly (p < 0.05) associated with changes in methylation at 23 genes, with 6 surviving FDR correction. T-tests were then performed for the 23 CpG sites that met nominal significance to assess whether there was significant differential methylation in the resilient group relative to the non-resilient group. Nine CpG sites demonstrated significant resilience-associated methylation differences as well as differential methylation when compared to the susceptible group. The results of this study identify potential candidate genes associated with resiliency and contribute to the growing body of literature seeking to identify resiliency markers in humans.
Issue Date:2019-04-24
Type:Text
URI:http://hdl.handle.net/2142/105080
Rights Information:Copyright 2019 Brianna Bucknor
Date Available in IDEALS:2019-08-23
Date Deposited:2019-05


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