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Title:Mechanistic interrogations of ribosomal and non-ribosomal natural product enzymes
Author(s):Cogan, Dillon P.
Director of Research:Nair, Satish K.
Doctoral Committee Chair(s):Nair, Satish K.
Doctoral Committee Member(s):van der Donk, Wilfred A.; Gerlt, John A.; Rienstra, Chad M.
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):biosynthesis
natural product
enzyme
RiPP
ribosomal
peptide
polyketide
non-ribosomal
DNA-binding
thiopeptide
lanthipeptide
Abstract:Described herein is my thesis work towards structural and biochemical characterization of bacterial proteins involved in metabolite regulation and natural product biosynthesis. In the first case, I will describe the structural basis for transcriptional regulation of a small molecule metabolite, p-coumarate, and the remaining cases involve enzymes responsible for biosyntheses of complex natural products. Among the natural product cases are those falling under the class of ribosomally synthesized and post-translationally modified peptides (RiPPs), with a particular emphasis on the thiopeptide subclass of RiPPs. Additionally, characterization of an off-loading enzyme involved in hybrid polyketide/non-ribosomal peptide (PK-NRP) natural product biosynthesis is described.
Issue Date:2019-04-08
Type:Text
URI:http://hdl.handle.net/2142/105160
Rights Information:Copyright 2019 Dillon Cogan
Date Available in IDEALS:2019-08-23
Date Deposited:2019-05


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