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Title:Using light to control and investigate cell biology
Author(s):Khamo, John S.
Director of Research:Zhang, Kai
Doctoral Committee Chair(s):Zhang, Kai
Doctoral Committee Member(s):Shapiro, David J.; Procko, Erik; Yang, Jing
Department / Program:Biochemistry
Discipline:Biochemistry
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Optogenetics
Cell Signaling
Carbon Dots
Abstract:It is no surprise that light plays an important role in life. With the development of modern technologies, light has also proven to be a powerful tool for the interrogation of molecular and cellular biology. Beyond its use in microscopic applications, light has emerged as an attractive modulator of cellular function. Within the last two decades, scientists have begun to harness the power of light and light-sensitive moieties to synthetically alter molecular processes in living cells. In combination with more conventional experimental techniques, this approach has allowed for the precise elucidation of many biological mechanisms that underpin development and disease. Here, I report on recent advances in optobiological techniques and their application in cell biology. I also include a novel study on the optogenetic delineation of growth factor signaling in neuronal development. Finally, I report on the spectroscopic analysis of fluorescent nanoparticles with potential biological utility.
Issue Date:2019-06-06
Type:Text
URI:http://hdl.handle.net/2142/105591
Rights Information:Copyright 2019 John S. Khamo
Date Available in IDEALS:2019-11-26
Date Deposited:2019-08


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