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Title:Pattern De-liver-ed
Author(s):Jain, Ishita
Abstract:Let us begin with this amazing fact about our livers - almost 2/3rds of your liver can be transplanted to another human being, and it'll grow back to its original size in both the bodies. However, in many liver diseases, the liver fails to regenerate. Understanding this process of regeneration and liver formation in healthy and diseased conditions is the broad area of my research. This image is one of the 1000 micro-liver tissues that I have made and studied. Serendipitously, we found that when we have liver stem cells on a circular shape, they pattern themselves. The cells on the periphery, the green circular blobs here, become the bile duct forming cells and the cells in the center become hepatocytes, which form the majority of the liver. This circular sheet of cells then become an excellent model to study how the liver patterns itself during development and regeneration. The red colour in the picture represents the boundary of the cell. We quantify the intensity of the red signal, giving us information about how cells are interacting with each other. Using similar metrics, I am deciphering how multiple cells talk to each other and decide to build a multifunctional system.
Issue Date:2020
Rights Information:Copyright 2020 Ishita Jain
Date Available in IDEALS:2020-04-14

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