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Title:IMPACT OF THE OH-TO-F REPLACEMENTS IN MONOSACCHARIDES
Author(s):Alonso, Elena R.
Contributor(s):Cocinero, Emilio J.; Boutureira, Omar ; Corzana, Francisco ; Basterretxea, Francisco J.; Castillón, Sergio ; Salvadó, Miriam ; Escudero Casao, Margarita ; Mestre, Jordi ; Prieto, Pedro J.; Calabrese, Camilla ; Insausti, Aran
Subject(s):Conformers and isomers
Abstract:\begin{wrapfigure}{r}{0pt} \includegraphics[scale=0.8]{abstractv4.eps} \end{wrapfigure} Bioisosteric OH-to-F replacements, concretely those produced in saccharides, have become a cornerstone in the development of novel drugs and tracers for the non-invasive imaging modalities, like \mbox{($^{19}$F-MR/MRI)} and ($^{18}$F-PET). F and OH groups are isoelectronic and possess similar polarity and steric impact. Despite its remarkable purposes, there is a lack of knowledge about the structural non-covalent interactions involving F in their native context, which are the key in the activities that they develop. By means of high resolution rotational spectroscopy in combination with a laser ablation\footnote{C. Calabrese, I.Uriarte, A. Insausti, M. Vallejo-López, F.J. Basterretxea, S.A. Cochrane, B.G. Davis*, F. Corzana*, E.J. Cocinero*. \textit{ACS Cent. Sci.} \textbf{2020}, \underline{6}, 2, 293-303}$^{,}$\footnote{C. Calabrese, P. Écija, I. Compañón, M. Vallejo-López, A. Cimas, M. Parra, F.J. Basterretxea, J.I. Santos, J. Jiménez-Barbero, A. Lesarri, F. Corzana*, E.J. Cocinero*. \textit{J. Phys. Chem. Lett.} \textbf{2019}, \underline{10}, 12, 3339-3345}, we are able to isolate and characterize the intrinsic conformational structures of these fluorinated saccharides, obtaining valuable information about their structure and connection with their biological properties.
Issue Date:24-Jun-20
Publisher:International Symposium on Molecular Spectroscopy
Citation Info:APS
Genre:CONFERENCE PAPER/PRESENTATION
Type:Text
Language:English
URI:http://hdl.handle.net/2142/107328
Date Available in IDEALS:2020-06-26


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