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Title:Mathematical modeling of infectious diseases
Author(s):Ahmed, Iftikhar
Director of Research:Rapti, Zoi
Doctoral Committee Chair(s):DeVille, Lee
Doctoral Committee Member(s):Zharnitsky, Vadim; Caceres, Carla
Department / Program:Mathematics
Discipline:Mathematics
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Epidemic Models
Wolbachia
Optimal Control
Daphnia
Dynamical Systems
Partial Differential Equations
Abstract:In this dissertation, we studied mathematical models of infectious diseases that consist of ordinary differential equations (ODEs) and partial differential equations (PDEs). An ODE model is formulated to describe the dynamics of wild mosquitoes when Wolbachia-infected female and male mosquitoes are introduced in the wild as a biological control, where we assume imperfect maternal transmission of Wolbachia to offspring and incomplete cytoplasmic incompatibility. In order to reduce the population of wild mosquitoes with minimal release of Wolbachia-infected mosquitoes in the wild, we develop an optimal control model. The optimal controls are found by using the Pontryagin's Maximum Principle. We also formulated an ODE optimal control model to describe the dynamics of dengue-infected humans when Wolbachia-infected mosquitoes are introduced in the wild along with efforts on educational campaigns to motivate individuals for using personal protection in order to reduce humans-mosquitoes. In this optimal control model, we also determined the most cost-effectiveness control strategy among different control interventions to reduce dengue infections in humans. In the host (Daphnia)- parasite (fungal spores) system, we study the disease dynamics of Daphnia in a water column where both algae and spores sink and diffuse. We formulated the Daphnia-spores-algae model using advection-diffusion partial differential equations (PDEs). We studied the effects of algal carrying capacity, sinking rates of algae and spores, and the water column maximum depth on the disease dynamics of Daphnia.
Issue Date:2020-04-09
Type:Thesis
URI:http://hdl.handle.net/2142/108229
Rights Information:Copyright 2020 Iftikhar Ahmed
Date Available in IDEALS:2020-08-27
Date Deposited:2020-05


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