Model and analysis of MoS2 nanopore biomolecule detection via membrane current

Abstract

A microscopic model of MoS2 nanopore transverse current biosensor is built based on Boltzmann transport formalism. The model employs a self-consistent Poisson-Boltzmann scheme for the interaction among ions, charge carriers around the pore rim, and biomolecules. In combination with experimental study and molecular dynamics (MD) calculation, a comprehensive physical analysis of various resistive effects involved in the electronic detection of a single biomolecule in a nanopore of a MoS2 nanoribbon is presented. The analysis emphasizes the effects of the electrolyte concentration, pore size, and nanoribbon geometry on the electrical sensitivity of the nanopore in detecting biomolecules. The study also provides explanation of the experimental observation of the effects of the doping polarity and biomolecule charge polarity on the electrical sensing signal.