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Title:Model-based myelin water fraction mapping: analyses and improvement
Author(s):Xiong, Jiahui
Advisor(s):Liang, Zhi-Pei
Department / Program:Electrical & Computer Eng
Discipline:Electrical & Computer Engr
Degree Granting Institution:University of Illinois at Urbana-Champaign
Subject(s):myelin water fraction
sensitivity analysis
Bayesian estimation
Cramér-Rao lower bound
Abstract:In this thesis, the problem of model-based myelin water fraction (MWF) mapping is addressed. We first focus on three of the most widely used signal models for T2*-myelin water imaging (MWI), i.e., the NNLS-multi-exponential model, the magnitude-3-exponential model, and the complex-3-exponential model, and investigate their sensitivities to practical perturbations such as random noise and field-related structured errors. We demonstrate through both Cramér-Rao lower bound (CRLB) analyses and Monte Carlo simulations that the three signal models are all very unstable inherently. Comparatively speaking, however, we demonstrate the theoretical advantage of the 3-exponential models over the multi-exponential model in handling noise, and the practical advantage of the magnitude models over the complex model in handling phase-related perturbations for T2*-MWI. We also illustrate the necessity and effects of incorporating various types of constraints for additional sensitivity gain. Using the insights obtained in the sensitivity analyses, we then propose a new MWF fitting scheme that leverages an improved signal model and a set of more effective constraints. In particular, a relaxed magnitude-3-exponential model with additional frequency compensation terms is introduced to better represent voxels with large field variations; a set of statistical distributions learned from in vivo training data is further imposed on the model parameters for additional constraints. Using phantom simulation and in vivo experiments, we then evaluate and compare the proposed method with several popular conventional MWF fitting schemes to demonstrate the improved accuracy and robustness of the proposed method. In this thesis, a literature review on the study of myelin and the development of MWF mapping is provided at the start of the work. Background materials on the CRLB theories are also provided to facilitate reading.
Issue Date:2020-11-18
Rights Information:Copyright 2020 Jiahui Xiong
Date Available in IDEALS:2021-03-05
Date Deposited:2020-12

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