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Title:Biological Controls for Standardization and Interpretation of Adaptive Immune Receptor Repertoire Profiling
Author(s):Trück, Johannes; Eugster, Anne; Barennes, Pierre; Tipton, Christopher M.; Luning Prak, Eline T.; Bagnara, Davide; Soto, Cinque; Sherkow, Jacob S.; Payne, Aimee S.; Lefranc, Marie-Paule; Farmer, Andrew; The AIRR Community; Bostick, Magnolia; Mariotti-Ferrandiz, Encarnita
Subject(s):B-cell Receptor (BCR)
IG
T-cell Receptor (TCR)
TR
antibody
immunoglobulin
immunology
inflammation
next generation sequencing (NGS)
Abstract:Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad clinical and diagnostic applications. However, like many high-throughput technologies, it comes with several problems, and the AIRR Community was established to understand and help solve them. We, the AIRR Community's Biological Resources Working Group, have surveyed scientists about the need for standards and controls in generating and annotating AIRR-seq data. Here, we review the current status of AIRR-seq, provide the results of our survey, and based on them, offer recommendations for developing AIRR-seq standards and controls, including future work.
Issue Date:2021-05-26
Publisher:eLife Sciences Publications
Citation Info:Johannes Trück et al., Biological Controls for Standardization and Interpretation of Adaptive Immune Receptor Repertoire Profiling, 10 eLife e66274 (2021)
Genre:Article
Type:Text
Language:English
URI:http://hdl.handle.net/2142/110324
DOI:10.7554/eLife.66274
Date Available in IDEALS:2021-08-12


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