Files in this item



application/pdfs13073-017-0475-4.pdf (276kB)
(no description provided)PDF


Title:Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic
Author(s):Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S.; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn P.; Chalmers, Don; Chan, Sarah; Charlesworth, Jac; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne L.; Hewitt, Alex W.; Kamens, Joanne; Kato, Kazuto; Kleiderman, Erika; Kodama, Satoshi; Liddicoat, John; Mackey, David A.; Newson, Ainsley J.; Nielsen, Jane; Wagner, Jennifer K.; McWhirter, Rebekah E.
Subject(s):Somatic Cell Therapy
Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)
Genome Editing
Stakeholder Engagement Mechanisms
Abstract:Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
Issue Date:2017-09-25
Publisher:Genome Medicine
Citation Info:Dianne Nicol et al., Key Challenges in Bringing Somatic Cell Therapy into the Clinic, 9 Genome Med. 85 (2017)
Date Available in IDEALS:2021-09-09

This item appears in the following Collection(s)

  • Illinois Research and Scholarship
    This is the default collection for all research and scholarship developed by faculty, staff, or students at the University of Illinois at Urbana-Champaign

Item Statistics