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Title:Key Challenges in Bringing CRISPR-Mediated Somatic Cell Therapy into the Clinic
Author(s):Nicol, Dianne; Eckstein, Lisa; Morrison, Michael; Sherkow, Jacob S.; Otlowski, Margaret; Whitton, Tess; Bubela, Tania; Burdon, Kathryn P.; Chalmers, Don; Chan, Sarah; Charlesworth, Jac; Critchley, Christine; Crossley, Merlin; de Lacey, Sheryl; Dickinson, Joanne L.; Hewitt, Alex W.; Kamens, Joanne; Kato, Kazuto; Kleiderman, Erika; Kodama, Satoshi; Liddicoat, John; Mackey, David A.; Newson, Ainsley J.; Nielsen, Jane; Wagner, Jennifer K.; McWhirter, Rebekah E.
Subject(s):Somatic Cell Therapy
Clustered Regularly Interspersed Short Palindromic Repeats (CRISPR)
Genome Editing
Stakeholder Engagement Mechanisms
Abstract:Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.
Issue Date:2017-09-25
Publisher:Genome Medicine
Citation Info:Dianne Nicol et al., Key Challenges in Bringing Somatic Cell Therapy into the Clinic, 9 Genome Med. 85 (2017)
Genre:Article
Type:Audio
Language:English
URI:http://hdl.handle.net/2142/110383
DOI:10.1186/s13073-017-0475-4
Date Available in IDEALS:2021-09-09


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