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Title:Micro-particles Immunoassays For Early Detection Of Ovarian Cancer Using Laser Induced Breakdown Spectroscopy.
Author(s):Karunanithy, Robinson
Contributor(s):Holland, Torrey E.; Sivakumar, P
Subject(s):Spectroscopy as an analytical tool
Abstract:Detecting cancer cells before any symptoms appear is essential for successful treatment, especially for epithelial ovarian cancer (EOC) with few or no symptoms at the early stages. Although there are methods that have been developed to identify the cancer cells, scientists are looking for other novel promising methods to detect that early stage, also cheap and user-friendly. Here, we cross-link elemental particles to a specific functional group of the targeted biomolecules based on a covalent and non-covalent linking chemistry to improve the sensitivity and the selectivity of biomarker detection. In this presentation, we look into the sandwich type of micro-particle immunoassay with pair of Fe3O4 and silicon micro-particles used for highly-selective detection of specific cancer antigen human epididymis protein-4 (HE4) in which U.S. Food and Drug Administration (FDA) accepted recently as a biomarker for monitoring EOC patients. The cancer biomarkers are quantified via detecting the silicon using Laser-induced breakdown spectroscopy (LIBS).
Issue Date:2021-06-24
Publisher:International Symposium on Molecular Spectroscopy
Genre:Conference Paper / Presentation
Date Available in IDEALS:2021-09-24

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