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 Title: The Shape Of Levodopa: A Laser Abalation Rotational Study Author(s): Novo, Miguel Sanz Contributor(s): Alonso, José L.; León, Iker; Alonso, Elena R. Subject(s): Structure determination Abstract: The rotational spectrum of neutral levodopa (L-dopa), an aminoacid precursor of neurotransmitters dopamine \footnote{C. Cabezas, I. Pena, J. C. Lopez and J. L. Alonso, J. Phys. Chem. Lett., 2013, 4, 486–490.}, norepinephrine (noradrenaline) and epineophrine (adrenaline), has been investigated for the first time using a broadband chirped pulse FTMW spectrometer coupled with a laser ablation source (LA-CP-FTMW). The spectroscopic parameters derived from the analysis of the spectrum conclusively identify the existence of three conformers of levodopa. The $^{14}$N nuclear quadrupole coupling constants have been analyzed, probing the existence of stabilizing N-H-$\pi$ interactions for the observed structures. \begin{itemize} \item \textbf{Acknowledgments:} The authors thank the financial fundings from Ministerio de Ciencia e Innovacion (CTQ2016-76393-P and PID2019-111396GB-I00), Junta de Castilla y Leon (VA077U16 and VA244P20) and European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC-2013-SyG, Grant Agreement n. 610256 NANOCOSMOS, are gratefully acknowledged. E.R.A. acknowledges MINECO for a Juan de la Cierva postdoctoral fellowship and the Fundación Biofísica Bizkaia (Spain). M.S.N. acknowledges funding from the Spanish "Ministerio de Ciencia, Innovación y Universidades" under predoctoral FPU Grant (FPU17/02987). \end{itemize} Issue Date: 2021-06-24 Publisher: International Symposium on Molecular Spectroscopy Genre: Conference Paper / Presentation Type: Text Language: English URI: http://hdl.handle.net/2142/111495 Date Available in IDEALS: 2021-09-24
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