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Title:Chronic Wasting Disease In Cervids: Prevalence, Impact And Management Strategies.
Author(s):Rivera, Nelda A.; Brandt, Adam L.; Novakofski, Jan E.; Mateus-Pinilla, Nohra E.
Contributor(s):Helms, Kerry L. (Scientific Illustrator)
Subject(s):CWD
prion
PRNP
PrPC
PrPSC
TSE
Abstract:Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) that affects members of the cervidae family. The infectious agent is a misfolded isoform (PrPSC) of the host prion protein (PrPC). The replication of PrPSC initiates a cascade of developmental changes that spread from cell to cell, individual to individual, and that for some TSEs, has crossed the species barrier. CWD can be transmitted horizontally and vertically, and it is the only TSE that affects free-ranging wildlife. While other TSEs are under control and even declining, infection rates of CWD continue to grow and the disease distribution continues to expand in North America and around the world. Since the first reported case in 1967, CWD has spread infecting captive and free-ranging cervids in 26 states in the US, 3 Canadian provinces, 3 European countries and has been found in captive cervids in South Korea. CWD causes considerable ecologic, economic and sociologic impact, as this is a 100% fatal highly contagious infectious disease, with no treatment or cure available. Because some TSEs have crossed the species barrier, the zoonotic potential of CWD is a concern for human health and continues to be investigated. Here we review the characteristics of the CWD prion protein, mechanisms of transmission and the role of genetics. We discuss the characteristics that contribute to prevalence and distribution. We also discuss the impact of CWD and review the management strategies that have been used to prevent and control the spread of CWD.
Issue Date:2019-06-18
Publisher:Dove Medical Press
Citation Info:Rivera, Nelda A., Adam L. Brandt, Jan E. Novakofski, and Nohra E. Mateus-Pinilla. "Chronic wasting disease in cervids: Prevalence, impact and management strategies." Veterinary Medicine: Research and Reports 10 (2019): 123.
Series/Report:Veterinary Medicine: Research and Reports. 2019;10:123.
Genre:Journal (whole)
Article
Type:Text
Language:English
URI:https://doi.org/10.2147/VMRR.S197404
http://hdl.handle.net/2142/111763
Sponsor:the US Fish and Wildlife Service Federal Aid in Wildlife Restoration Project (W-146-R)
the Illinois Natural History Survey-Prairie Research Institute
University of Illinois Office of the Vice Chancellor for Research
Rights Information:Open access under CC BY license
Date Available in IDEALS:2021-10-23


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