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Title:Peripheral perfusion imaging modeling
Author(s):Zhu, Yang
Director of Research:Insana, Michael F
Doctoral Committee Chair(s):Insana, Michael F
Doctoral Committee Member(s):Sutton, Brad; Dobrucki, Wawrzyniec; Oelze, Michael L
Department / Program:Bioengineering
Discipline:Bioengineering
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Ultrasound power Doppler
scatterer statistics
clutter filtering
basis decomposition
independent and principal component analyses
Abstract:Effective clutter and noise filtering is critical for contrast-free ultrasonic per- fusion imaging. Novel pulsed-Doppler methods for perfusion imaging are val- idated using dialysis cartridges as perfusion phantoms. Techniques are exam- ined quantitatively at 5 and 12.5 MHz using phantoms with blood-mimicking fluid flow within cellulose microfibers. A variety of flow states are assessed to measurement sensitivity and flow accuracy. Comparisons between phantom and preclinical images show that peripheral perfusion imaging can be reliably achieved without contrast enhancement. One goal is to examine methods for setting the parameters of higher-order singular value decomposition (HOSVD) clutter filter and characterize blood and clutter components. 1-D and 2-D echo simulators are used to model in various flow states and clutter motion with exactly known signals. We explore the strengths and limitations of principal component analysis (PCA) and independent component analysis (ICA) for clutter and noise filtering. PCA methods excel when the echo covariance exhibits a significant blood- scattering component orthogonal to the tissue clutter component. Another goal is to improve the reliability and adaptivity of the HOSVD filter. We evaluate the performance of normalized cross-correlation (NCC) displacement estimation algorithm and Fourier-based registration methods. The remarkable advantage of image registration methods and their ability to help reduce the bandwidth of coherent clutter motion improves the performance of clutter filter on peripheral perfusion imaging.
Issue Date:2021-06-21
Type:Thesis
URI:http://hdl.handle.net/2142/113124
Rights Information:Copyright 2021 Yang Zhu
Date Available in IDEALS:2022-01-12
Date Deposited:2021-08


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