Analysis of the expression and effects of vascular endothelial growth factor family of molecules on Fragile X Syndrome abnormalities in a mouse model (2017-04-21)Fragile X Syndrome (FXS) is the most common form of inherited mental retardation affecting 1:3600 males and 1:8000 females (Cornish et al., 2008). The primary cause is a silencing of the FMR1 gene, via increased CGG ...
Expression and regulation of the rate-limiting enzymes of the kynurenine pathway in the mouse brain (2017-04-20)During the mid-1900’s, early anti-depressants were developed to increase levels of catecholamines within the brain, leading to the theory that depression symptomology was a result of an imbalance of neurotransmitters within ...
(2017-03-15)Neural plasticity, the ability of neural tissue to adapt to a number of environments, is considered a defining characteristic of the brain. However, plasticity is poorly understood at the systems level. The exact limits ...
Understanding the role of cerebrovascular health in cognitive aging: a multi-modal noninvasive human neuroimaging approach (2016-09-30)The brain’s vasculature undergoes age-related physiological and anatomical changes similarly to the rest of the cardiovascular system. However, the health of the cerebrovasculature may be related to cognitive ability. Thus, ...
(2016-08-08)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental disorder which manifests as deficits in impulse control, excessive activity in home or school settings, and an inability to focus ...