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Title:Studies of protein folding on membranes and in crowded environments and bridging the research-teaching gap in K-12 science
Author(s):Denos, Sharlene
Director of Research:Gruebele, Martin
Doctoral Committee Chair(s):Gruebele, Martin
Doctoral Committee Member(s):Clegg, Robert M.; Crofts, Antony R.; Gennis, Robert B.
Department / Program:School of Molecular & Cell Bio
Discipline:Biophysics & Computnl Biology
Degree Granting Institution:University of Illinois at Urbana-Champaign
Degree:Ph.D.
Genre:Dissertation
Subject(s):Proteins
Protein Folding
Crowding
Science Education
Science Outreach
Membrane Proteins
Peptide Design
Abstract:This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble trans-membrane helices from known membrane proteins, and the characterization of membrane binding of single surface and trans-membrane helices. I then describe the effects of excluded volume on the stability and kinetics of a stable Lambda Repressor mutant Y22WQ33YA3749G. Finally, I discuss two education projects that aim to bridge the gap between scientific research and K-12 teaching.
Issue Date:2010-01-06
URI:http://hdl.handle.net/2142/14567
Rights Information:Copyright 2009 Sharlene Denos
Date Available in IDEALS:2010-01-06
Date Deposited:December 2


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