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Single molecule study of weak and transient biological interactions

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Title: Single molecule study of weak and transient biological interactions
Author(s): Cisse, Ibrahim
Director of Research: Ha, Taekjip
Doctoral Committee Chair(s): Chemla, Yann R.
Doctoral Committee Member(s): Goldenfeld, Nigel D.; Stack, John D.
Department / Program: Physics
Discipline: Physics
Degree Granting Institution: University of Illinois at Urbana-Champaign
Degree: Ph.D.
Genre: Dissertation
Subject(s): Single Molecule Weak Interactions Transient Interactions Protein-DNA Interactions DNA-DNA Interactions RNA-RNA Interactions Protein-Protein Interactions
Abstract: Over the past decade, major breakthroughs were led in molecular biology with techniques allowing the study of dynamics at the resolution of an individual molecule. We have been expanding this capability by adapting porous vesicle encapsulation to single molecule fluorescence techniques. The porous vesicle encapsulation method allows the study of individual macromolecules in a biofriendly, cell-like environment, where the chemical condition can be changed and the desired reactions are triggered at will. Specifically, this adaptation now allows the study of weakly and transiently interacting biomolecules at the single-molecule resolution. Here we present unique interactions between proteins and nucleic acids which were previously unattainable with conventional single molecule techniques.
Issue Date: 2010-01-06
Rights Information: Copyright 2009 Ibrahim Cisse
Date Available in IDEALS: 2010-01-06
Date Deposited: 2009-12

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