Dept. of Chemistry
(2015-03-04)Nitrogen functionality is ubiquitous in biologically active molecules, from naturally occurring alkaloids and peptides to synthetic pharmaceuticals. However, due to its promiscuous reactivity, nitrogen can be challenging ...
Less toxic yet still resistance evasive amphotericins and atomistic probing of the amphotericin B ion channel (2015-01-22)Amphotericin B (AmB) is a polyene macrolide natural product with two major functions: antifungal activity and ion channel formation. For over 50 years AmB has remained the last line of defense against systemic fungal ...
Synthetic diversity in C-H activation: development of selective and efficient C-H functionalization reactions (2015-01-08)The past century has witnessed tremendous advancements in both organic methodology and total synthesis. With the synthetic conquest of molecular giants such as amphotericin and brevetoxin A, it becomes increasingly apparent ...
(2015-03-05)Surface-enhanced Raman scattering spectroscopy (SERS) was combined with the diamond anvil cell technique to study molecular monolayers and single molecules under high pressure. Vibrational spectra up to 8 GPa were obtained ...
(2015-02-20)The complex structural dynamics of materials systems involved in the production and storage of energy are examined in order to provide insight into the understanding and design of more effective systems. Within this ...