Palladium-catalyzed cross-coupling of γ-substituted allylic silanolates with aryl bromides was investigated. It was discovered that γ-selectivity is heavily influenced by the substituents at silicon. It is proposed that ...

The transmetalation mechanism was examined through the natural abundance 13C NMR kinetic isotope effect (KIE) studies. This provided evidence for either palladium-olefin complexation or a Heck-type carbometalation as the ...

Finally, an E,Z-1,4-bissilylbutadiene reagent was prepared for the synthesis of unsymmetrical, highly conjugated systems. Two distinct silyl substituents were differentiated in the cross-coupling reaction through the initial ...

Mechanistic investigations of the palladium-catalyzed cross-coupling of aryldimethylsilanolates demonstrated that transmetalation proceeds directly from an arylpalladium(II) silanolate intermediate without external activation. ...

Pd/PVP catalyzed H-D exchange in substituted pyridines and other nitrogen containing heterocyclic compounds was followed using 1H-NMR spectroscopy. Substitution at the position alpha to the endocyclic nitrogen was favored ...

Biologically active extracts of the Caribbean sponges Agelas coniferin and Agelas cf. mauritiana have been found to contain seven new bromopyrroles (1a, 3a-8a), as well as the known debromooroidin-dimer sceptrin (2a). These ...

Part B. Progress towards a new family of hyperbranched polymers based on the condensation of an AB$\sb2$ 9-phenylcarbazole monomer 169 has been described. Initial condensation reactions have provided material of greater ...

Finally, the syntheses of site-specifically deuterated arachidonic acids containing a remote tritium label are reported. These radiolabeled substrates would allow the characterization of the initial radical intermediate ...

Two aromatic fluorination methods, the decomposition of aryl azides and the decomposition of aryl triazenes, were investigated as methods potentially suitable for fluorine-18 labeling of estrogens. The aryl triazene method ...