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Browse Dissertations and Theses - Chemistry by Contributor "Mitchell, Douglas A"
Now showing items 1-20 of 20
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Biochemical characterization of enzymes involved in the biosynthesis of the thiopeptide thiomuracin (2018-12-20)Clinically significant antibiotic resistance has evolved against virtually every antibiotic currently deployed, therefore it is critical for human health to discover new antibacterial agents with novel modes of action. ...
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PDF (8MB)
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(2016-06-29)Plantazolicin (PZN) is a ribosomally synthesized and post-translationally modified peptide (RiPP) natural product that exhibits extraordinarily narrow-spectrum antibacterial activity towards the causative agent of anthrax, ...
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PDF (17MB)
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(2016-07-01)Elucidation of the molecular mechanisms of cancers has enabled the development of molecularly targeted chemotherapeutics capable of exploiting cancer-specific cellular alterations. Small-molecule activation of procaspase-3 ...
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PDF (22MB)
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(2017-10-04)New antibiotics to combat drug-resistant Gram-negative pathogens are urgently needed. Most small molecules are unable to rapidly traverse the outer membrane of Gram-negative bacteria and accumulate inside these cells, ...
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PDF (13MB)
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(2016-11-18)Bacterial secondary metabolites have historically been a rich source of antibiotic compounds. The genomic era has shown that bacteria harbor the potential to produce even more natural products that could be developed into ...
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PDF (28MB)
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(2017-07-26)Proteins and RNA are known to be enzymes in nature. These biopolymers have complex secondary and tertiary structures that can enable substrate binding and catalysis. DNA is primarily double-stranded and is not known to be ...
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(2017-07-10)Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products. RiPP precursor peptides can undergo extensive enzymatic tailoring to yield structurally and ...
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PDF (39MB)
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(2016-11-29)Natural product discovery is in the midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided ...
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PDF (63MB)
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(2017-04-20)The ability to make multiplexed measurements has significantly improved our understanding of disease onset and progression. This newfound understanding has the potential to transform clinical diagnostics. Also known as ...
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PDF (7MB)
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(2019-04-15)Despite remarkable medical advances, including improved sanitation, effective vaccines, and antibiotics, bacterial infections remain a serious threat to human health. Annually, over 17 million people succumb to bacterial ...
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PDF (52MB)
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Mass spectrometry-based characterization of cell-to-cell signaling molecules in the nervous system (2016-09-02)Cell-to-cell signaling molecules are an important class of endogenous molecules which are responsible for cell-to-cell communication within organisms. Small molecules and peptides work as neurotransmitters and neuromodulators ...
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PDF (5MB)
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(2017-11-29)Precision medicine offers the potential to transform healthcare by utilizing detailed biochemical insights into a patient’s disease state for therapeutic decision-making. Numerous disease specific biomarkers have emerged, ...
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(2017-12-07)Natural products, generally defined as metabolites of biotic origin, have a long history as medicines and have remained a fruitful source of new drug leads for multiple diseases in the modern age. Arguably the largest asset ...
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PDF (28MB)
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(2017-11-28)Traditional approaches in the pharmaceutical industry center around the development of small molecule therapeutics that bind to and inhibit overactive protein function. This has been transformational in the treatment of ...
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(2015-01-21)The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large ...
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PDF (45MB)
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(2019-02-20)The continual rise of microbial resistance is a pressing concern throughout the world, resulting in several thousands of deaths each year. Most of these deaths are a result of Gram-negative infections as no new class of ...
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PDF (20MB)
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(2015-10-12)Infectious diseases are a continuing threat to human health. In particular, the rapid development of bacterial antibiotic resistance not only decreases the effectiveness of known antibiotics, but also increases the need ...
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PDF (75MB)
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(2018-03-13)Lipid peroxidation has long been correlated to and proposed to be a causative factor in a myriad of human diseases. However, identifying a causative mechanistic role of lipid peroxidation has proven challenging and the ...
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PDF (33MB)
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(2016-07-06)Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity ...
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(2015-09-10)My graduate research has focused on demonstrating the concept of a contact-initiated, or touch-and-go, reaction. One of the foundational concepts of organic chemistry is that an intermolecular reaction can only occur once ...
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PDF (3MB)
Now showing items 1-20 of 20