Clinically significant antibiotic resistance has evolved against virtually every antibiotic currently deployed, therefore it is critical for human health to discover new antibacterial agents with novel modes of action. ...

Elucidation of the molecular mechanisms of cancers has enabled the development of molecularly targeted chemotherapeutics capable of exploiting cancer-specific cellular alterations. Small-molecule activation of procaspase-3 ...

Bacterial secondary metabolites have historically been a rich source of antibiotic compounds. The genomic era has shown that bacteria harbor the potential to produce even more natural products that could be developed into ...

Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a rapidly growing class of natural products. RiPP precursor peptides can undergo extensive enzymatic tailoring to yield structurally and ...

The ability to make multiplexed measurements has significantly improved our understanding of disease onset and progression. This newfound understanding has the potential to transform clinical diagnostics. Also known as ...

Cell-to-cell signaling molecules are an important class of endogenous molecules which are responsible for cell-to-cell communication within organisms. Small molecules and peptides work as neurotransmitters and neuromodulators ...

Natural products, generally defined as metabolites of biotic origin, have a long history as medicines and have remained a fruitful source of new drug leads for multiple diseases in the modern age. Arguably the largest asset ...

The thiazole/oxazole-modified microcins (TOMMs) are a recently grouped class of ribosomally synthesized and posttranslationally modified peptides. Encoded by many bacteria and archaea, these natural products occupy a large ...

Infectious diseases are a continuing threat to human health. In particular, the rapid development of bacterial antibiotic resistance not only decreases the effectiveness of known antibiotics, but also increases the need ...

Poly(ADP-ribose) synthesis and degradation are important cellular processes associated with the DNA damage response and many other pathways. Traditionally, these processes have been challenging to study due to the heterogeneity ...