# Browse Dissertations and Theses - Chemistry by Contributor "Oldfield, Eric"

• (1988)
Proton and Carbon-13 "Magic Angle" Sample Spinning (MASS) NMR is shown to yield high-resolution spectra for a variety of fluid liquid crystalline phases. Relatively slow ca. 3-kHz MASS causes averaging of the ...

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• (2017-04-19)
In principle, nuclear magnetic resonance (NMR) spectroscopy provides structural and conformational information with sub-Angstrom precision and the ability to measure dynamics with timescales ranging from femtoseconds to ...

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PDF (22MB)
• (2012-02-01)
Lantibiotics are polycyclic antimicrobial peptides that are ribosomally synthesized and posttranslationally modified to their biologically active forms. The recently discovered lantibiotic epilancin 15X produced by ...

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• (1991)
We have obtained high-field (11.7 T), high-resolution $\sp{13}$C solid state "magic angle" sample spinning nuclear magnetic resonance (MAS NMR) spectra of a variety of model phospholipids, sphingolipids, myelin and white ...

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• (2001)
The research in this thesis represents an effort to better understand the structure of proteins, and to suggest new spectroscopic information which might be used to improve the resolution of such structures. Variations in ...

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• (2006)
Using the above mentioned 3D-QSAR methods we have developed predictive models of the inhibition of human farnesyl pyrophosphate synthase (FPPS), important for osteoclast function and survival as well as Trypanosoma brucei ...

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• (2011-05-25)
The emergence of resistance to cancer treatments through methods that generate cell death by inducing DNA damage, such as chemotherapeutics and radiation therapy, is a major obstacle to overcoming the disease. Resistance ...

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PDF (17MB)
• (1990)
This thesis is devoted to the new applications of high resolution $\sp1$H and $\sp{13}$C "magic angle sample spinning" (MASS) nuclear magnetic resonance (NMR) techniques to the study of model and biological membranes. Since ...

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• (2005)
A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth ...

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• (2018-12-19)
Phosphonic and phosphinic acid natural products are characterized by their carbon-phosphorus bonds, and exhibit a variety of bioactivities. Further, these compounds often contain unusual structural features, which arise ...

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• (2014-05-30)
Bacterial polyprenyl transferases transfer polyprenyl groups onto molecular acceptors, such as proteins and small molecules, and they are very important functional entities that are involved in bacterial cell wall biosynthesis, ...

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PDF (16MB)
• (1996)
We have used a multinuclear approach to study proteins in the work described in this dissertation. We first studied fluorine labeled avian egg white lysozymes. Mutagenesis and other chemical modification methods were used ...

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PDF (8MB)
• (1991)
The quadrupolar interaction having an electrostatic origin, reveals itself in a variety of ways in NMR spectroscopy. In solids, where motions are highly restricted, the quadrupolar interaction is anisotropic and orientation ...

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PDF (4MB)
• (1988)
High field carbon-13 and oxygen-17 nuclear magnetic resonance (NMR) spectra have been obtained for a variety of transition metal carbonyl clusters, metal oxides, and oxide-supported metal carbonyl complexes. Magic-angle ...

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• (2001)
The overall objective of this research is to develop new chemotherapeutic approaches for the treatment of parasitic protozoan diseases. The work presented in this thesis focuses on the design, synthesis, and screening (in ...

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• (1999)
In this thesis I describe how density functional theory methods can be combined with NMR spectroscopy to determine ligand binding geometries in organometallic complexes and heme proteins. Results of density functional ...

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• (2004)
In this work, we describe the development of computational models to predict nuclear magnetic resonance (NMR) and Mossbauer spectroscopic properties in heme proteins and model systems by using quantum chemical techniques. ...

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• (2018-04-16)
The secondary coordination sphere of metalloenzymes is implicated in controlling nuclearity, enhancing substrate selectivity, and stabilizing reactive intermediates, and is thus essential in promoting the reactivity of the ...

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PDF (14MB)
• (1990)
In this study, solid state nuclear magnetic resonance (NMR) spectroscopy is used to investigate the structural, electronic, and dynamical properties of a variety of high temperature oxide superconductors and metal carbonyls ...

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• (1989)
This study presents $\sp{17}$O NMR spectra of randomly and magnetically oriented samples of various high-$T\sb{c}$ superconductors. Systems under investigation include: (BaK)BiO$\sb3$, La$\sb{1.85}$Sr$\sb{0.15}$CuO$\sb4$, ...

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