School of Molecular and Cellular Biology
(2019-12-12)Over the last two decades, synthetic biology has emerged as a critical toolset for genetic engineering. Synthetic gene circuits have been engineered for a variety of uses from functional modules to increasing biosynthetic ...
(2019-12-02)Small molecules are an important part of how bacteria survive, primary metabolites are involved in growth and development while secondary metabolites can function as signaling molecules, scavengers or chemical weapons. ...
Solid-state NMR structural investigations of alpha-synuclein fibrils derived from Lewy Body dementia brain tissue (2019-11-27)Amyloid fibrils composed of the neural protein α-synuclein (α-syn) are the primary proteinaceous constituent of insoluble deposits in the brain that are the defining pathological feature of neurodegenerative diseases, ...
(2019-11-21)Two-dimensional (2D) materials have transformed single molecule nanoscale manipulation and molecular detection. Graphene is one such 2D material whose single-atom thickness and high in-plane electrical conductivity enables ...
Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning (2019-11-19)Experimental analysis of protein mutations is classically a ‘small data’ problem. A limited number of mutants are made at sites of suspected importance, and the activity of each variant is individually tested. However, by ...