School of Molecular and Cellular Biology
(2015-01-21)Cadherins are cell-cell adhesion proteins that mediate cell recognition, segregation, and signaling in many tissues. Recent findings demonstrated that type I classical cadherin complexes are mechanosensitive. Mechanical ...
(2015-01-21)In eukaryotic cells, the genome is packed into fundamental units called nucleosomes, where 147 base pairs of DNA are wrapped around a protein core. Stable packing of DNA in nucleosomes imposes a barrier for accessibility ...
Mining the enolase superfamily for new functions: investigations of D-glucarate dehydratase related proteins (GlucDRP) and L-lyxonate dehydratase proteins (LyxD) (2015-01-21)Genomic era begins with development of sequencing methods. Genome sequencing is now cost-effective and fast, giving rise to increasing amounts of genomic data. However, the function of 1% of the deposited sequences have ...
In vitro selection and characterization of mono-, di-, and trivalent metal-dependent DNAzymes and their sensing applications (2015-01-21)Since the discovery of nucleic acid enzymes and aptamers that can perform functional roles other than storing genetic information; a new paradigm in nucleic acid chemistry has been opened. In 1990 the first artificially ...
(2015-01-21)Molecular chaperones have evolved to support the general stability and maintenance of the cellular proteome. Through their broad binding capacity, transient interactions, and high cellular abundance, the Hsp70 and Hsp90 ...