School of Molecular and Cellular Biology
(2015-12-02)Metal ions are essential for numerous biological processes and their regulation is crucial for maintaining normal functions. To gain a better fundamental understanding of how metal ions are regulated and where the potential ...
Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis (2015-11-17)Human history is also a history of the ceaseless fight against various diseases, especially those caused by pathogenic infections. Both scientists and pharmaceutical companies have been dedicated in developing antimicrobial ...
Mechanistic studies of class II lanthipeptide synthetases and yeast surface display of lanthipeptide leader peptides (2015-11-17)Lanthipeptides are natural products that belong to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs). They contain the characteristic lanthionine (Lan) or methyllanthionine (MeLan) ...
Biochemical characterization of enzymes involved in the post-translational modification of lantibiotics (2015-11-10)Lantibiotics are ribosomally-synthesized and post-translationally modified peptides (RiPPs) characterized for exerting antimicrobial activity against bacterial strains resistant to commonly used antibiotics. During lantibiotic ...
The interactions of cytochrome bo3 from Escherichia coli with its substrates - ubiquinone and oxygen (2015-11-02)Heme-copper respiratory oxygen reductases reduce O2 to water and use the redox free energy to generate the proton motive force. Among the heme-copper oxygen reductases are the quinol oxidases, which catalyze the 2-electron ...