School of Molecular and Cellular Biology
Understanding the molecular mechanism on cell surface receptor interaction of helicobacter pylori vacuolation cytotoxin (2017-12-01)Chronic infection with the human specific gastric pathogen Helicobacter pylori (H. pylori) is a risk factor for the development of gastric ulcer disease and gastric adenocarcinoma. The vacuolating cytotoxin (VacA) is a ...
(2017-10-20)CYP17A1 and CYP19A1 are the key cytochromes P450 involved in steroidogenesis. Mutations causing hypo- or hyper-activation of both these enzymes results in diseased states, including cancers. In addition to carrying out ...
Characterizing a structural and functional model of nitric oxide reductase performing NO and O2 reduction in engineered myoglobin (2017-10-30)Nitric oxide reductase (NOR) is a membrane-bound metalloenzyme in the denitrification pathway of many bacteria. NORs are structurally homologous to subunit I of HCOs (heme-copper oxidases); however, the copper site (CuB) ...
Identification of a conserved alternative mRNA splicing program that supports hepatic growth and maturation during development and regeneration (2017-09-22)Analysis of metazoan genomes has led to the extraordinary observation that mammals contain only ~25000 protein-coding genes. Therefore, post-transcriptional gene regulatory mechanisms (PTGRMs) are thought to be crucial for ...
Theoretical and computational investigations into structure-function relationships of biomolecular machines at atomic resolution (2017-07-14)Molecular machines play vital roles in many cellular processes, including DNA replication and repair, gene expression, protein degradation, protein secretion and maintenance of pH homeostasis. Despite intense research ...