Dept. of Biochemistry

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  • Bao, Zehua (2017-04-10)
    Biological functions of a cell are encoded within its genome and regulated through complex genetic networks. Direct manipulation of the genome and the transcriptome in multiplex enables study of gene-gene interactions and ...

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  • Walsh, Shannon M (2017-02-10)
    Nature has developed the use of proteins and RNA as enzymes, while DNA is used for the storage and transfer of genetic information. Proteins and RNA are biopolymers that can fold into specific secondary and tertiary ...

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  • Cioffi, Alexander Geoffrey (2017-01-13)
    Human diseases caused by an excess of protein function can often be treated with small molecules that bind and inhibit the corresponding proteins. In contrast, there are many currently incurable human diseases that are ...

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  • Lawrence, Gus (2017-04-20)
    Lysosomes solve fundamental obstacles to the evolution of complex life forms. Lysosomes sense and maintain cellular metabolic stores and ensure their judicious use. More importantly, lysosomes respond to changes in osmotic ...

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  • Frimel, Aaron Michael (2016-12-08)
    The mitochondrial Leucyl-tRNA synthetase (mtLeuRS) of certain Caenorhabditis species contains an idiosyncratic C-terminal addition. Bioinformatic analyses identified this domain in the mtLeuRS and also four putative nuclear ...

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