# Browse Dept. of Biochemistry by Title

• (2013-05-24)
Initiation of the coagulation cascade in vivo is mediated by tissue factor (TF), which functions as the cell surface receptor and catalytic cofactor for factor VIIa (FVIIa), as well as the mediator for the autoactivation ...

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• (1994)
To better understand the role of specific residues of hemoglobin in allosteric function, cooperative interactions, ligand discrimination and protein-protein recognition, a genetic handle is required. The use of total gene ...

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• (2014-01-16)
It is generally agreed that many proteins are structurally dynamic; sampling many conformations while in solution and also adopting new conformations upon complexation with a ligand. Many of these flexible enzymes are of ...

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• (1991)
To investigate the mechanism of transcription termination by bacteriophage RNA polymerases, templates encoding variants of the transcription-termination structure in the regulatory region of the threonine (thr) operon of ...

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• (2003)
Human papillomaviruses (HPVs) are one of the most common sexually transmitted pathogens in the world. The American Social Health Association reports that there are at least 20 million Americans already infected with HPVs ...

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• (1985)
A combination of cloned DNA fragments encoding the yeast GAL7 gene, yeast plasmid vectors, chromosomal gal7 deletion strains, and GAL regulatory mutants were used to characterize the in vitro transcription of the GAL7 ...

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• (1995)
Black swallowtail (Papilio polyxenes) is an oligophagous insect feeding exclusively on plant species which contain toxic furanocoumarins. P. polyxenes owes its tolerance to furanocoumarins to at least one cytochrome P450 ...

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• (2002)
I propose that a trans-acting regulatory protein binds to the pyrG GGGC and GCUCCC sequences when intracellular CTP levels are low, which prevents the formation of the terminator and permits transcription readthrough. ...

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• (1996)
A complete transcript of the Bacillus subtilis pyr operon contains the following elements in 5$\sp\prime$ to 3$\sp\prime$ order: a 150 nt untranslated leader; pyrR, which encodes a 21 kDa protein; a 173 nt intercistronic ...

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• (1978)

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• (1989)
Initiation of translation in eukaryotes is believed to occur by a scanning mechanism in which the 40s ribosomal subunit recognizes the 5$\sp\prime$ terminal cap structure (m$\sp7$G(5$\sp\prime$)ppp(5$\sp\prime$)N$\...$) ...

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• (2003)
In Chapter 5, we investigated the complementation and activity of a methylesterase phosphorylation point mutant, C-terminal truncated mutant, and a serine active site mutant in vivo to the attractant asparagine to determine ...

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• (2013-02-03)
The characterization of the ω protein, eventually renamed to Escherichia coli Topoisomerase I (EcoTopoI), by Prof. James C Wang opened the door to the previously unknown world of molecular machines that manipulate DNA ...

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• (2001)
This work demonstrates the usefulness of combining high pressure techniques with theoretical calculations. Through the use and development of high pressure methods, a better understanding of the factors involved in ...

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• (1997)
The mechanism of membrane domain formation was investigated through analysis of domains induced both by calcium and myelin basic protein in vesicles containing components normally enriched in myelin. In the presence of ...

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• (1985)
The application of high hydrostatic pressures (1 atm - 3 kbar) has long been known to lead to the dissociation of oligomeric proteins due to the negative volume change accompanying this process. This technique coupled with ...

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• (2009)
Finally, soluble high-affinity TCRs are promising reagents for the detection and diagnosis of specific virus or tumor antigens (peptide-MHC) on the cell surface. In addition, the TCRs would provide a useful probe for ...

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• (1985)
Models have proposed that recognition of specific DNA sequences by proteins is accomplished by specific hydrogen bond formation between the protein and groups accessible in the major and minor grooves of the DNA. We have ...

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• (2009)
Directional translocation by helicases results in duplex separation and displacement of bound proteins which allows for the DNA processing events associated with DNA repair, replication, recombination, and transcription. ...

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• (2000)
The isolation of t-s smp3, gaa1, and gpi2 strains using a synthetic lethality screen demonstrates that this is a valid approach to identify genes involved in GPI anchor biosynthesis. This suggests that many of the remaining ...

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