Respiring organisms derive energy mainly from electron transfer reactions that are coupled to the translocation of ions across the cell membrane. This process is performed by a group of membrane-localized protein complexes ...

CYP17A1 and CYP19A1 are the key cytochromes P450 involved in steroidogenesis. Mutations causing hypo- or hyper-activation of both these enzymes results in diseased states, including cancers. In addition to carrying out ...

Human diseases caused by an excess of protein function can often be treated with small molecules that bind and inhibit the corresponding proteins. In contrast, there are many currently incurable human diseases that are ...

Cytochrome P45017A1 (CYP17A1) is a multifunctional steroidogenic enzyme responsible for the 17-hydroxylation of pregnenolone and progesterone as well as the subsequent 17,20 carbon-carbon bond scission of its hydroxylated ...