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Browse Dept. of Biochemistry by Contributor "Jonas, Ana"
Now showing items 1-14 of 14
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(1997)High density lipoproteins (HDL) can be fractionated by immunoaffinity chromatography into two main subclasses: a fraction which contains apolipoprotein (apo) AI and apoAII, and a fraction which contains apoAI but not apoAII. ...
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(1988)Discoidal-reconstructed high density lipoproteins (rHDL) were used to study the effect of HDL substrates on phosphatidylcholine (PC) transfer by human plasma phospholipid transfer protein (PLTP) by changing the composition ...
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(2001)LCAT glycosylation mutants N84Q and N384Q were examined to determine the effects of deleting individual glycan chains. Purified N84Q LCAT did not possess measurable enzymatic activity or interfacial binding affinity for ...
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(1994)The esterification of cholesterol on high density lipoproteins (HDL) catalyzed by lecithin:cholesterol acyltransferase (LCAT) maintains a gradient for cholesterol diffusion from cell membranes and atherosclerotic plaques ...
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Factors affecting the reaction of lecithin cholesterol acyltransferase with water-soluble substrates (1990)To separate interfacial binding from the catalytic reactions of LCAT, the first investigation of its reaction with water soluble substrates was performed to characterize the molecular specificity of the active site as well ...
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(1990)The effects of pressure, up to 5 kbar, on phospholipid vesicles were measured using high pressure NMR techniques. Specifically, two sets of experiments were performed. First, sonicated vesicles of 1-palmitoyl-2-oleyl-3-s ...
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(1996)The cDNA coding the human proapoA-I was cloned into an Escherichia coli vector, overexpressed and purified to 99% homogeneity and characterized together with apoA-I purified from human plasma. SDS-PAGE, mass spectrometry ...
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(1998)These results have established further relationships between LCAT and other interfacially activated lipases and have contributed to the understanding of the functional regions of LCAT.
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(2000)Based on this study and previous results, a model of lipid-free proapoAI was constructed. This model takes into account the elongated shape of proapoAI, indicates that the N- and C-terminal extremes of proapoAI are compact, ...
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(1995)Spontaneous lipid transfers are important components in the metabolism of low density lipoprotein (LDL) and high density lipoprotein (HDL). Cholesterol spontaneously transfers from LDL to HDL; phospholipid transfer proceeds ...
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(1996)Limited proteolysis was used to study the domain structure and to produce a large N-terminal fragment of human apolipoprotein A-I (apoA-I). Digestion of reconstituted high density lipoprotein (rHDL) prepared with apoA-I ...
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(2000)Our main research objective is to investigate the effects of high pressure on the structure, stability, and dynamics of proteins. The application of pressure provides a unique method to reversibly unfold proteins. Pressure ...
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(1990)High density lipoprotein (HDL) is believed to be involved in reverse cholesterol transport. HDL consists primarily of phospholipids, cholesterol, cholesterol esters, and apolipoprotein A-I (apo A-I). However, HDL is extremely ...
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The study of spherical high-density lipoproteins and the intermediates involved in their formation (1993)High density lipoproteins (HDL), which are found as spherical particles in the circulation, contain a core of neutral lipids, mainly cholesterol esters and an outer shell of apolipoproteins, phospholipids, and cholesterol. ...
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Now showing items 1-14 of 14