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Browse Dept. of Biochemistry by Contributor "Kalsotra, Auinash"
Now showing items 1-9 of 9
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(2018-12-05)Heme-copper oxidases (HCOs) couple the free energy of oxygen reduction and translocate protons across membrane to generate a proton electrochemical gradient, which was used to produce ATP by ATP synthase. Based on the ...
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(2020-12-03)My thesis focuses on understanding the functional role of SRSF1, a prototypical splicing factor, in the context of liver physiology. I began by generating and characterizing hepatocyte-specific SRSF1 knock-out mice models. ...
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(2016-07-22)The T cell receptor (TCR) is an heterodimer that binds to a short peptide bound to a product of the major histocompatibility complex (MHC). The chains each contain variable (V) and constant (C) region domains, followed ...
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(2020-07-14)Epigenetic regulation of gene expression plays essential roles in controlling normal cellular functions as well as abnormal cellular activities in human diseases like inflammatory diseases and cancers. The bromodomain-containing ...
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(2017-09-22)Analysis of metazoan genomes has led to the extraordinary observation that mammals contain only ~25000 protein-coding genes. Therefore, post-transcriptional gene regulatory mechanisms (PTGRMs) are thought to be crucial for ...
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(2019-12-04)How a complex multicellular organism forms from a single cell is a question that defies simplistic understanding. Yet, embryonic developmental programs use a surprisingly small set of signaling pathways to pattern the ...
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(2020-05-07)Signaling pathways extensively crosstalk among each other and result in different cellular phenotypes depending on the dynamic profile of protein activity. Conventional genetic and pharmacological approaches such as gene ...
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(2015-07-14)While the basic outline of the enzymes and reactions that make up the traditional blood coagulation cascade has been understood for many years, appreciation of the complexity of these interactions has greatly increased in ...
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(2021-07-09)Heart disease remains the leading cause of death in the United States. Despite what is known about the risk factors associated with heart disease, the molecular mechanisms are still largely ambiguous. Cardiomyocytes are ...
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Now showing items 1-9 of 9