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Browse Dept. of Biochemistry by Contributor "Lu, Yi"
Now showing items 1-20 of 21
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(2018-12-05)Heme-copper oxidases (HCOs) couple the free energy of oxygen reduction and translocate protons across membrane to generate a proton electrochemical gradient, which was used to produce ATP by ATP synthase. Based on the ...
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(2015-04-17)Heme copper oxygen reductases (HCOs) are key enzymes for aerobic respiration. As a terminal electron acceptor, HCO catalyzes the sequential transfer of four electrons from reduced cytochromes c on the P-side of the membrane, ...
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(2012-06-27)An engineered variant of the electron transfer catalyst Azurin - a cupredoxin cloned from Pseudomonas aeruginosa - has recently been created, in an attempt to demonstrate the power of the secondary coordination sphere ...
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(2017-10-30)Nitric oxide reductase (NOR) is a membrane-bound metalloenzyme in the denitrification pathway of many bacteria. NORs are structurally homologous to subunit I of HCOs (heme-copper oxidases); however, the copper site (CuB) ...
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(2015-12-02)Metal ions are essential for numerous biological processes and their regulation is crucial for maintaining normal functions. To gain a better fundamental understanding of how metal ions are regulated and where the potential ...
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(2015-05-14)Gram negative and positive bacteria have evolved toxins to aid in their ability to colonize host organisms. Some gram-positive bacteria produce exotoxins called superantigens that hyper-stimulate the immune system by ...
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Engineering of transcription activator-like effector nucleases (TALENs) for targeted genome editing (2013-08-22)In the post-genome era, one of the most important topics of research is to edit or program genomic sequences and to generate desired phenotypes. Although virus-based strategies have long been developed to for efficient ...
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(2007)Novel oxygen reactivity is observed in our model protein (CuBMb) which reproduces the most essential components of HCO active site. In order to improve this artificial model to inhibit its side reaction with oxygen and ...
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(2013-02-03)Nature has given nucleic acids irreplaceable roles for all living creatures. It plays important roles in genetic information storage and transfer, as well as regulating various aspects of biology. The discovery of in vitro ...
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(2015-01-21)Since the discovery of nucleic acid enzymes and aptamers that can perform functional roles other than storing genetic information; a new paradigm in nucleic acid chemistry has been opened. In 1990 the first artificially ...
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(2006)The characterization of two families of Co2+-dependent DNAzymes further demonstrates the interplay between DNAzyme structure and metal specificity. The clone 11 and 18 DNAzymes were selected for study because the primary ...
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(2021-07-13)Beyond the function of carrying genetic information, the recognition function (DNA aptamers), the structural function (DNA origami and DNA nanodevices), and most interestingly, the catalytic function (deoxyribozymes or ...
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(2015-10-08)Metalloproteins are a fascinating class of proteins that function at the heart of several important biological processes including photosynthesis, respiration, and nitrogen fixation. It is even more amazing, considering ...
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(2006)Protein engineering by rational design has been used to study heme proteins and artificial Mn-salen containing metalloenzymes using heme protein scaffolds. Heme proteins perform a wide variety of functions including the ...
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(2013-05-28)This thesis aims at developing novel methods of cost-effective on-site quantitative assays of multiple targets using functional DNA and portable instruments. Such assay methods are important for personal care as well as ...
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(2010)In summary, a means to investigate the specific function of individual metal ligand residues in azurin and CuA azurin by using EPL to incorporate nonproteinogenic amino acid analogues has been demonstrated. This work has ...
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(2010-08-31)Metalloproteins play important roles in biological systems since metal-binding sites are found in ~ 1/3 of structurally characterized proteins and in ~ 1/2 of all proteins. Despite progress, the role of these metal-binding ...
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(2015-07-17)The bc1 complex of the electron transport chain is critical to production of ATP through the proton gradient driven by quinone oxidation; a ubiquitous mechanism for energy conversion throughout the biosphere. In addition ...
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(2012-02-01)Proteins are involved in nearly every process that occurs in living systems, either as a main participant in the process or preforming a supporting role. It is estimated that approximately half of proteins in living systems ...
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(2013-08-22)Pre-mRNA splicing in plants is mechanistically the same as splicing in other eukaryotes, but its mode of intron recognition is unique. Whereas in animals a pyrimidine-tract contributes to the definition of exons, in plants, ...
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Now showing items 1-20 of 21