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Browse Dept. of Biochemistry by Contributor "Morrissey, James H."
Now showing items 1-20 of 23
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(2007)RNA and DNA editing, occurring by way of hydrolytic deamination of cytidine (C) and adenosine (A), is a modification event that profoundly effects on an organisms vitality and quality of life. This study focuses on two ...
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(2010-01-06)Blood coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these ...
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(2013-05-28)In case of an injury platelets become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the ...
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(2010-01-06)In the genomic era, advanced sequencing techniques have enabled an exponential growth of the protein sequence databases. Although the abundance of genomic sequences is valuable, the correctness of the gene annotations ...
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(2013-02-03)The regulation of protease activity is essential for physiological events, such as angiogenesis, inflammation, wound healing, and tumor invasion. Urokinase plasminogen activator receptor (u-PAR) has been widely studied ...
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Engineering of transcription activator-like effector nucleases (TALENs) for targeted genome editing (2013-08-22)In the post-genome era, one of the most important topics of research is to edit or program genomic sequences and to generate desired phenotypes. Although virus-based strategies have long been developed to for efficient ...
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(2015-04-21)Staphylococcus aureus and group A Streptococcus express a family of exotoxins including staphylococcal enterotoxins A, B, C (SEA, SEB, SEC), toxic shock syndrome toxin-1 (TSST-1) and streptococcal pyrogenic exotoxins (SpeA, ...
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(2010-08-31)High-throughput screening (HTS) has played an integral role in the discovery of lead molecules that eventually are transformed into the therapies of tomorrow. Contributing towards the success of any screening campaign ...
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(2010-01-06)Abstract The two-component based chemotaxis signal transduction system allows flagellated bacteria to sense their surrounding chemical environment and move towards more favorable conditions. The attractant signals can ...
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(2013-05-24)Fusion at highly specialized membrane microdomains is a prerequisite for processes like hormone and neurotransmitter release, antigen presentation and viral infection. Apart from a family of highly conserved proteins called ...
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(2016-04-22)The goal of my research has been to investigate the mechanisms by which inorganic polyphosphate (polyP) is degraded in vivo. PolyP is a linear chain of phosphate moieties linked through high-energy phosphoanhydride bonds ...
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(2015-01-21)Genomic era begins with development of sequencing methods. Genome sequencing is now cost-effective and fast, giving rise to increasing amounts of genomic data. However, the function of 1% of the deposited sequences have ...
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(2017-04-10)Biological functions of a cell are encoded within its genome and regulated through complex genetic networks. Direct manipulation of the genome and the transcriptome in multiplex enables study of gene-gene interactions and ...
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(2016-10-11)Protein-membrane interactions are a critical component of the coagulation cascade. For many coagulation factors, these interactions are mediated via γ-carboxyglutamate rich regions, or GLA domains, in a Ca2+-dependent ...
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(2015-07-14)While the basic outline of the enzymes and reactions that make up the traditional blood coagulation cascade has been understood for many years, appreciation of the complexity of these interactions has greatly increased in ...
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(2013-02-03)Polyphosphate (polyP) is a linear polymer of inorganic phosphates that is secreted by activated platelets and is abundant in many pathogenic microorganisms. Our lab has recently shown that polyP from bacteria and human ...
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(2013-05-28)Maintenance of eukaryotic cellular homeostasis requires the fusion of vesicle membranes that is accomplished by a SNARE-mediated mechanism. Membrane fusion is the merger of two lipid bilayers into one continuous membrane. ...
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(2013-08-22)The sensing of lipopolysaccharide (LPS) represents a major mechanism of detection of Gram-negative bacterial infection by the human innate immune system. This pathogen associated molecular pattern is recognized by the ...
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(2015-01-21)Orotidine 5’-monophosphate decarboxylase (OMPDC) is the last enzyme in the de novo pyrimidine biosynthetic pathway. It catalyzes the decarboxylation of orotidine 5’-monophosphate (OMP) to uridine 5’-monophosphate (UMP), ...
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(2014-09-16)A structural homology model of Butirosin D is presented. This enzyme has been previously re-characterized as a deacetylase, releasing a free acetate molecule when acting upon the substrate 2’-N-acetylparomamine. The ...
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Now showing items 1-20 of 23