In the post-genome era, one of the most important topics of research is to edit or program genomic sequences and to generate desired phenotypes. Although virus-based strategies have long been developed to for efficient ...

DNA lies at the base of the central dogma of life. Altering DNA enables modification of information flow carried on by fundamental cellular processes like transcription and translation. The ability to precisely manipulate ...

Nuclear organization has an important role in determining genome function; however, it is not clear how spatiotemporal organization of the genome relates to functionality. To elucidate this relationship, a method for ...

Enzymes have been used for decades for the industrial production of high value chemicals such as food additives, antibiotics and other pharmaceutical products. However, in recent years the significant advances in biocatalyst ...

From DNA replication and repair to transcription and translation, all aspects of molecular biology are governed by interactions between proteins and nucleic acids. Some of the nucleic acid-binding proteins have evolved ...