# Browse Dissertations and Theses - Biochemistry by Title

• (1994)
I have investigated signal recognition particle (SRP)-mediated protein targeting using a combination of genetic, biochemical, and molecular sequence analysis techniques. First, I consider the SRP cycle from the perspective ...
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• (1995)
Structural and functional properties of wild type and mutant forms of cytochrome $bo\sb3$ quinol oxidase from E.coli were examined. Structural properties of subunit II were addressed with the restoration of the putative ...
PDF (11MB)
• (1996)
In the first part of this work we provide evidence indicating that under standard cell culture conditions unliganded estrogen receptor (ER) is unable to activate transcription. Studies of Chinese Hamster Ovary cells which ...
PDF (4MB)
• (1996)
In the first part of this work we provide evidence indicating that under standard cell culture conditions unliganded estrogen receptor (ER) is unable to activate transcription. Studies of Chinese Hamster Ovary cells which ...
PDF (4MB)
• (1990)
The cytochrome d terminal oxidase is one of two terminal oxidases in the aerobic respiratory chain of E. coli. The topology of the two subunits of the complex were examined by the use of alkaline phosphatase gene fusions, ...
PDF (2MB)
• (1996)
The genes encoding the enzymes for de novo pyrimidine biosynthesis in the gram-positive microorganism Bacillus subtilis were previously shown to be clustered at 139 min on its chromosome, transcribed from a single promoter ...
PDF (9MB)
• (1994)
The induction of the Xenopus estrogen receptor mRNA by its ligand, estradiol-17$\beta$ (E$\sb2$), results in the establishment of a permanent autoregulatory loop. In order to identify the element(s) responsible for the ...
PDF (3MB)
• (1989)
A single, transient dose of estradiol-17$\beta$ is sufficient to elicit the permanent induction of hepatic estrogen receptor mRNA, which is induced 18-fold, from 0.13 molecules/cell to 2.4 molecules/cell, and then remains ...
PDF (4MB)
• (1990)
Protein translocation across the endoplasmic reticulum of higher cells is dependent on a ribonucleoprotein complex known as signal recognition particle (SRP). SRP is composed of six polypeptides and one molecule of 7SL ...
PDF (4MB)
• (1990)
I have examined the small RNA profile of the fission yeast Schizosaccharomyces pombe. In vivo labeling followed by two dimensional gel electrophoresis of S. pombe RNA demonstrates the presence of four prominent species in ...
PDF (6MB)
• (1996)
Microtubules are essential organelles found in almost all eukaryotic cells. Some of their diverse functions include intracellular transport, cell division and maintenance of cell shape. Microtubules are composed of highly ...
PDF (5MB)
• (1993)
Bacterial chemotaxis may be considered the archetype for the behavioral response by organisms to environmental stimuli. The movement of bacteria toward various chemical substances depends upon the ability of the organism ...
PDF (5MB)
• (1996)
Bacterial chemotaxis is one of the most well understood signal transduction processes in biology. By controlling the direction of flagella rotation, this process allows the organism to sense changes in its surroundings and ...
PDF (4MB)
• (1993)
The Cytochrome P-450 class of monoxygenases carry out a wide variety of hydroxylation, epoxidation and heteroatom oxidation reactions. The cytochrome P-450cam enzyme from P. putida has been widely studied as a model for ...
PDF (8MB)
• (2010-01-06)
Blood coagulation requires the assembly of several membrane-bound protein complexes composed of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these ...
PDF (5MB)
• (2010-01-06)
Cadherins are calcium dependent cell adhesion molecules. The interaction between cadherin molecules is important in establishing cell polarity, tissue identity and tissue boundary. This study focused on the mechanism of ...
PDF (6MB)
• (1996)
Cytochromes P-450 form a large superfamily of heme-containing monooxygenases that are found in species ranging from bacteria to insects, plants, and mammals. In insects, P-450s have several functional roles, including ...
PDF (5MB)
• (2012-06-27)
An engineered variant of the electron transfer catalyst Azurin - a cupredoxin cloned from Pseudomonas aeruginosa - has recently been created, in an attempt to demonstrate the power of the secondary coordination sphere ...
PDF (1MB)
• (1995)
The T cell receptor (TCR) is a cell surface protein that specifically binds to a foreign antigen on the surface of another cell. The TCR is made up of two disulfide-linked chains (called $\alpha$ and $\beta$) each containing ...
PDF (5MB)
• (1993)
Cytotoxic T lymphocytes (CTL) recognize and lyse cells presenting viral or tumor-associated antigens associated with class I major histocompatibility complex proteins. Recognition occurs between the T cell receptor (TCR) ...
PDF (6MB)