Center for Biophysics and Computational Biology
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(2019-01-11)Computational studies of biological systems have evolved significantly, to the point where we can combine quantitative information on the expression of thousands of proteins and RNAs in large models of metabolism or gene ...
(2019-02-15)Transport of the nutrients across the cell membrane is regulated by membrane transport proteins which selectively and efficiently transports materials across the membrane. In the present work I focus on the family of ...
Complex, non-native heteronuclear metal centers designed in cytochrome c peroxidase: Expanding the limits of biosynthetic modeling (2018-12-04)Multielectron redox reactions often require enzymes with active sites that contain one or more metal centers, called metalloenzymes. Metalloenzymes may contain single metal ions, such as iron or copper, bound to the protein ...
(2018-11-30)Nuclear speckles have been studied intensively for a long time. Accumulating evidence has suggested that nuclear speckles have a dynamic structure, and are associated with a significant fraction of active chromosome regions ...
(2018-07-06)Protein folding, a ubiquitous and vital biological process, where protein random coil transforms into certain conformation in order to fulfill its function. Misfolded protein which fails to acquire proper shape, not only ...