Center for Biophysics and Computational Biology
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Theoretical and computational investigations into structure-function relationships of biomolecular machines at atomic resolution (2017-07-14)Molecular machines play vital roles in many cellular processes, including DNA replication and repair, gene expression, protein degradation, protein secretion and maintenance of pH homeostasis. Despite intense research ...
(2017-05-26)Many cellular functions rely on the movements of molecular motors. Single molecule studies of these motors allow investigation into their step-sizes and stall forces. Such studies inevitably involve noise, which is inherent ...
Molecular insights into the mechanisms of transport and energy coupling in membrane transport proteins (2017-07-13)Membrane transport proteins are the main gatekeepers controlling the traffic of molecules in and out the cell. The mechanism by which they mediate selective and regulated transport across the membrane is of broad physiological ...
(2017-07-09)No two living cells are exactly the same. Even cells from a clonal population with identical genomes living in the same environment will express proteins in different numbers simply due to the random nature of the chemistry ...
(2017-07-10)Besides the role of genetic information storage, DNA has been proposed as a new material in nanotechnology. The idea came from the nature-occurring Holliday junction (HJ) which allows more than 2 DNA strands to be assembled. ...