Center for Biophysics and Computational Biology
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The interactions of cytochrome bo3 from Escherichia coli with its substrates - ubiquinone and oxygen (2015-11-02)Heme-copper respiratory oxygen reductases reduce O2 to water and use the redox free energy to generate the proton motive force. Among the heme-copper oxygen reductases are the quinol oxidases, which catalyze the 2-electron ...
Computational investigations of protein dynamics and its implication in cellular functions: two cases on membrane sculpting by protein complexes and molecular origin of Parkinson's disease (2015-11-20)Proteins are complex machineries dedicated to drive many functions in eukaryotic cells. In this article, two cases of protein dynamics and their implications to cellular functions are discussed with computational approaches: ...
(2015-12-04)DNA fragments shorter than the persistence length display about five orders of magnitude higher flexibility than predictions of the semi-flexible polymer models based on its persistence length. Via single molecule cyclization ...
(2015-07-14)How simple is the underlying control mechanism for the complex locomotion of vertebrates? I explore this question for the free-swimming behavior of zebrafish larvae. A parameter-independent method, similar to that used in ...
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Supramolecular Architectures in Molecular Medicine: Visualizing and Manipulating the Structure of Protein-Lipid Surfaces (1999)In separate studies, myoglobin has been used to study the fluorescence lifetime behavior of oriented biomolecular surfaces. These studies have revealed differences in lifetime between differentially oriented myoglobin ...