Center for Biophysics and Computational Biology
Browse Collections of Items
(2017-04-20)Nucleic acids (e.g. DNA, RNA) are subjected to numerous twisting, bending, and stretching forces within cells, and enzymes process them in a variety of ways. The behavior of nucleic acids in response to applied forces and ...
(2017-04-21)This work seeks to duplicate a realistic membrane for a more natural model of the Rb. sphaeroides bc1 complex which in past studies has lacked several details in composition of the fatty acids and relative quantities of ...
(2017-04-21)The cytochrome bc1 complex and its family members play a central role in biological energy transduction across all domains of life, oxidizing QH2 in a bifurcated reaction which generates a proton-motive force used for ATP ...
Requirements and strategies for winning the battle against antibiotic resistance by antisense technology (2016-12-02)In chapter 1 we have investigated the different requirements and conditions for efficiency and specificity of antisense molecules. For specific therapy, an antibacterial RNA must be able to distinguish between its designed ...
Intracellular labeling of live cells via transient membrane permeabilization for fluorescence and super resolution microscopy (2016-07-20)Fluorescence imaging of intracellular proteins is often achieved by using transfection-induced expression of fluorescent protein. This can potentially impose artifacts such as loss of function or over-expression of target ...