# Browse Center for Biophysics and Computational Biology by Issue

• (2010-05-14)
In recent years, advances in nanotechnology have allowed researchers to manufacture pores in synthetic membranes with subnanometer precision, so-called synthetic nanopores. Immersed in aqueous solution, these nanopores can ...

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PDF (58MB)
• (2010-01-06)
This work deals with three important problems in membrane protein folding studies, namely the preparation and storage of homogeneous small unilamellar vesicles (SUV), the development of an algorithm for selecting soluble ...

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PDF (58MB)
• (2010-05-14)
Translation, the process of reading genetic information and synthesizing the corresponding proteins, is universal and found throughout the three domains of life. The flow of information in translation involves a series of ...

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PDF (14MB)
• (2010-05-14)
Cytochrome c oxidase is the terminal enzyme to accept electrons from cytochrome c in the respiratory chain of mitochondria, bacteria and archaea. It couples the reducing oxygen to water and pumping the protons across the ...

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PDF (1MB)
• (2010-05-14)
Cytochrome bo3 ubiquinol oxidase from E. coli is a member of heme-copper oxidase superfamily. This trans-membrane enzyme complex catalyzes two-electron oxidation of ubiquinol and reduction of molecular oxygen to water. ...

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• (1999)
Molecular complexes play a number of key roles in medicine and biology. Understanding how these complexes behave at interfaces, as well as controlling their structure, is of fundamental interest to science and technology. ...

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PDF (21MB)
• (2010-06-29)
The ribosome is a complex, dynamic molecular machine responsible for protein synthesis in all cells according to the genetic information. Recent breakthroughs in ribosome crystallography culminated with the 2009 Nobel Prize ...

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PDF (36MB)
• (2010-05-20)
Evolutionary transitions, times at which the behavior of evolution as a dynamic system dramatically changes, have occurred many times throughout the history of life on Earth. Carl Woese proposed that one such transition ...

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PDF (14MB)
• (2010-08-31)
The last decade has seen an explosion of data arising from the development and proliferation of high-throughput data gathering and analysis pipelines. In order to transform this data into useful hypotheses and conclusions, ...

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PDF (3MB)
• (2011-01-14)
Understanding the origins of life on Earth is one of the most intriguing problems facing science today. In the research presented here, we apply computational methods to explore origins of life scenarios. In particular, ...

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PDF (28MB)
• (2011-01-21)
Transcription factors play a vital role in the biology of every organism. By controlling gene expression they regulate growth, development, metabolism, reproduction, signaling, and response to the environment. They have ...

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PDF (3MB)
• (2011-01-14)
Two-photon (2P) excited fluorescence microscopy is particularly advantageous for imaging biological specimens since it offers reduced scattering, deep sample penetration, and intrinsic confocality when excited with point ...

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PDF (5MB)
• (1994)
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA ...

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PDF (3MB)
• (2011-05-25)
The folding of interphase chromatin into large-scale chromatin structure and its spatial organization within nucleus has been suggested to have important roles in gene regulation. In this study, we created engineered ...

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PDF (3MB)
• (2011-05-25)
“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. ...

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PDF (38MB)
• (2011-05-25)
The bacteria Rhodobacter sphaeroides uses photosynthetic reaction centers to convert light into chemical energy. Light absorption by the reaction center results in electron transfer through a series of cofactors, the ...

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PDF (9MB)
• (1996)
High resolution three dimensional structure of visual pigments is essential for understanding the visual process. The past few years have been an exciting period in the field of the structure of visual pigments. One of the ...

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PDF (4MB)
• (1990)
The kinetics and thermodynamics of the high potential chain in the chromatophores from Rhodobacter sphaeroides have been reexamined. It was found that RC, cyt c$\sb2$ and c$\sb1$ after a flash reached a state not far from ...

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PDF (5MB)
• (1994)
In biological systems, DNA/RNA-protein interactions as well as drug-DNA interactions play important roles in genetic processes. A fundamental understanding of these processes requires a detailed structural knowledge of ...

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PDF (6MB)
• (2010-01-06)
Aerobic organisms derive energy needed to sustain life from foodstuffs through the process of cellular respiration. Respiration is performed by a series of soluble and multi-subunit membrane proteins that form the ...

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PDF (2MB)