Browse Center for Biophysics and Computational Biology by Subject "Biology, Molecular"

• (1994)
In biological systems, DNA/RNA-protein interactions as well as drug-DNA interactions play important roles in genetic processes. A fundamental understanding of these processes requires a detailed structural knowledge of ...

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• (1998)
In this thesis, the effects of two inhibitors, funiculosin and zinc, on the $bc\sb1$ complex of Rhodobacter sphaeroides, and the role of isocyt $c\sb2$ in the photosynthetic chain were studied. Also the organization of the ...

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• (1994)
$\rm O\sp6$-ethyl-G $\rm (e\sp6G)$ is a persistent alkylation lesion of DNA, caused by the exposure of cells to alkylating agents such as N-ethyl-N-nitrosourea. Alkylating N-nitroso compounds are extremely significant as ...

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• (2003)
Complete prediction of the folding processes for complex protein molecules through first principles is currently not possible (2003). Here we take an empirical approach towards a better understanding of the protein-folding ...

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• (1996)
Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances ...

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• (2002)
SAR/MAR sequences have been hypothesized as forming the bases of DNA loops in metaphase chromosomes. To test the structural role of SAR/MAR sequences, we created stable cell lines containing chromosomes with regions of ...

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• (1996)
Properties of phospholipid membrane bilayers and of proteins associating and functioning in the membrane bilayer or at the membrane-water interface are studied by combining molecular dynamics simulations, free energy ...

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• (1990)
The ubiquinol:cytochrome c$\sb2$ oxidoreductase ($bc\sb1$ complex) is a central component of the mitochondrial respiratory chain as well as the respiratory and photosynthetic system of many prokaryotes. The fact that the ...

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• (1996)
Oxygenic photosynthesis converts light-energy into chemical free energy by reducing NADP$\sp+$ to NADPH and producing ATP. Eukaryotic plants and algae as well as prokaryotic cyanobacteria and prochlorophytes have a similar ...

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• (2000)
T:G mismatched base pair is associated with many genetic mutations. Understanding its biological consequences can be aided by studying the structural perturbation of DNA caused by T:G base pair and by specific probing of ...

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• (1993)
We have altered Glu$\sp{\rm M234}$ in reaction centers from Rhodobacter sphaeroides, replacing it with valine, glutamine and glycine to form mutants M234EV, M234EQ and M234EG, respectively. The absence of a formate-bicarbonate ...

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• (2006)
The creation of novel protein functions represents a significant challenge in protein engineering. To address this challenge, I have developed a simple and efficient method---in vitro coevolution---for the creation of novel ...

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• (2001)
The protein structure prediction problem consists of three separate subproblems: modeling the protein structure, modeling the protein energetics, and the problem of searching for low-energy structures in high-dimensional ...

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• (1996)
Heme proteins are ubiquitous in biological systems and it is of interest to understand how the structure of various heme proteins determines their respective biological function. Using site-directed mutagenesis, the amino ...

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• (1994)
Unusual DNA sequences are known to adopt interesting three-dimensional structures which might have important biological roles. For my thesis, I have tried to study the influence of various degrees of perturbations of DNA ...

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• (1991)
The structure of reaction centers (RCs) was modified with various sulfhydryl reagents. It was found that mercurial reagents, especially p-chloromercuribenzenesulfate (pCMBS), inhibit Q$\sb{\rm B}$ function in RCs from ...

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• (1999)
An HMG box is a DNA binding domain common to a large number of proteins whose diversity in function range from transcriptional activation and repression to chromatin assembly. These proteins can be viewed as two classes ...

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• (2001)
On the other hand, ssDNA-protein interaction is far less well understood than dsDNA-protein interactions. Gene V proteins from the filamentous phages are excellent systems for studying the interactions between protein and ...

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• (1996)
High resolution three dimensional structure of visual pigments is essential for understanding the visual process. The past few years have been an exciting period in the field of the structure of visual pigments. One of the ...

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• (2005)
Results of recent genome sequencing projects together with advances in biochemical, molecular genetic and physiological experimentation have allowed better understanding towards voltage-gated ion channels. The voltage-gated ...

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