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Browse Center for Biophysics and Computational Biology by Subject

Browse Center for Biophysics and Computational Biology by Subject "Helicase"

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Direct observation of XPD helicase base-pair stepping and regulation by RPA2

Qi, Zhi (2013-05-24)

Although it is known that single-stranded DNA binding proteins (SSB) can stimulate helicase activity, the mechanism by which this occurs may be more complex than sequestering ssDNA products of duplex separation. Here, ...

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Single-molecule study of the DNA helicase regulating genomic stability

Park, Jeehae (2012-02-01)

A DNA helicase, PcrA is an essential protein in gram-positive bacteria. PcrA utilizes its helicase activity and translocation activity to regulate various cellular functions including plasmid replication and counteracting ...

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Theoretical and computational investigations into structure-function relationships of biomolecular machines at atomic resolution

Ma, Wen (2017-07-14)

Molecular machines play vital roles in many cellular processes, including DNA replication and repair, gene expression, protein degradation, protein secretion and maintenance of pH homeostasis. Despite intense research ...

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