# Browse Dissertations - Biophysics and Computational Biology by Title

• (2005)
Cytochrome c oxidase, an integral membrane protein, is the final enzyme of the electron transport chain. The two sides of the membrane are denoted as the N side (the cytoplasmic side in bacteria and the matrix side of ...

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• (1975)

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• (1992)
We have analyzed the behavior of a linear, cyclic, four state model of regulation of contraction of smooth muscle. The model involves twenty one parameters: sixteen rate constants, three initial conditions, and NT$\sb3$ ...

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• (2013-05-28)
Myotonic dystrophy type 1 (DM1) is caused by an expanded CUG repeat (CUGexp) that sequesters muscleblind-like 1 protein (MBNL1), a protein that regulates alternative splicing. CUGexp RNA is a validated drug target for this ...

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• (1991)
Low intensity ultrasound (approximately 10$\sp{-6}$ W/cm$\sp2$) in the frequency range of 0.5 MHz to 5.0 MHz was employed to investigate biomembrane structural relaxation kinetics via absorption and velocity dispersion ...

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• (1999)
Binary dye mixtures were used to demonstrate the influence of the molecular brightness on the fluctuation amplitude G(0). This dependence allows to resolve multiple species based on the difference in their molecular ...

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• (2009)
Experimental methods in biology are generally able to provide low-resolution data on specific functions of biomolecules, or high-resolution data on structures and other properties in states of questionable physiological ...

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• (2002)
A versatile approach to modeling the conformations and energetics of DNA loops is presented. The model is based on the classical theory of elasticity, modified to describe the intrinsic twist and curvature of DNA, the DNA ...

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• (2008)
The goal of this research is to establish new drug targets and inhibitors against pathogens responsible for tropical and infectious diseases. Farnesyl diphosphate synthase, which forms farnesyl diphosphate in the isoprenoid ...

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• (2014-05-30)
Over the last several years, microfluidic-based techniques have been developed to study inducible gene expression at the single cell level, albeit without the ability to control external stimuli with precise methods. Most ...

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• (2011-05-25)
The folding of interphase chromatin into large-scale chromatin structure and its spatial organization within nucleus has been suggested to have important roles in gene regulation. In this study, we created engineered ...

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• (1998)
In this thesis, the effects of two inhibitors, funiculosin and zinc, on the $bc\sb1$ complex of Rhodobacter sphaeroides, and the role of isocyt $c\sb2$ in the photosynthetic chain were studied. Also the organization of the ...

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• (2015-07-14)
How simple is the underlying control mechanism for the complex locomotion of vertebrates? I explore this question for the free-swimming behavior of zebrafish larvae. A parameter-independent method, similar to that used in ...

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• (2011-05-25)
The bacteria Rhodobacter sphaeroides uses photosynthetic reaction centers to convert light into chemical energy. Light absorption by the reaction center results in electron transfer through a series of cofactors, the ...

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• (1995)
Magnetic resonance (MR) is a rapidly growing versatile and non-destructive tool for investigation of various aspects of biochemistry, physiology and disease. It is valuable to evaluate the new MR techniques and apply them ...

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• (1989)
Bacterium Rhodopseudomonas viridis has four c-type cytochromes integrated to a single protein subunit of the reaction center complex. Two of them are high redox midpoint potential hemes (cyt-c559; Em = 380 mV and cyt-c556; ...

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• (1991)
This thesis is a report of cation effects on the purple membrane of Halobacterium halobium. Included are proton and divalent cation studies using purple, blue, and pink membranes and the apoprotein. The blue species of ...

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• (1993)
Guinea pig left atria were suspended in a tissue bath of normal Krebs-Henseleit solution which was aerated with 95% O$\sb2$/5% CO$\sb2$ and maintained at 27$\sp\circ$C. The atria were attached to a force transducer and ...

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• (1983)
The contractile strength of heart muscle is strongly dependent on the rate of beating, and on the pattern of previous contractions over a period of many seconds. The activator calcium ions, which are responsible for the ...

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• (2004)
Near infrared spectroscopy (NIBS) has been used for determination of tissue optical properties. This technique has been especially useful for in vivo monitoring of hemodynamics and oxygen saturation in tissue. For this ...

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