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Browse Dissertations - Biophysics and Computational Biology by Title
Now showing items 111-130 of 311
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(1983)The binding of ligands to heme proteins has been studied extensively in the past. A sequential barrier model was postulated. Using flash photolysis, various aspects of the model are studied in this work to give a better ...
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PDF (3MB)
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(1999)The vestibular-ocular reflex (VOR) is a plastic system found in vertebrates which produces eye rotations that compensate for head rotations. Simultaneous motion and vision are thus possible since the reflex keeps vision ...
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PDF (8MB)
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(2011-05-25)“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. ...
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PDF (38MB)
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(2007)In this work we characterize the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over ...
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PDF (6MB)
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(2006)For decades there has only been anecdotal data regarding how difficult it is to crystallize membrane proteins but these facts are never rigorously evaluated, because virtually no one can report all the reasons why membrane ...
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PDF (3MB)
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(2013-05-24)Many types of diseases including cancer and autism are associated with copy-number variations in the genome. Most of these variations could not be identified with existing sequencing and optical DNA mapping methods. We ...
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PDF (3MB)
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(1996)Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances ...
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PDF (8MB)
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(1990)Hydroperoxide is required to activate prostaglandin endoperoxide synthase (PES) cyclooxygenase by formation of an enzyme-radical species (derived from a PES peroxidase intermediate), and is generated by the cyclooxygenase ...
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PDF (6MB)
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(1992)Melanins are complex, incompletely understood polymeric pigments which uniquely contain a stable population of organic free radicals amenable to study by electron paramagnetic resonance (EPR, or equivalently, electron spin ...
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PDF (14MB)
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Identification of the Impulse-Response Functions of a Non-Reflecting Monopolar Neuron and Its Parts (1988)In order to understand mechanistically how neurons process information, it is necessary to know how postsynaptic potentials and currents are propagated and integrated. In the present work the propagation of current was ...
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(2017-04-21)The cytochrome bc1 complex and its family members play a central role in biological energy transduction across all domains of life, oxidizing QH2 in a bifurcated reaction which generates a proton-motive force used for ATP ...
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(2006)Intimately associated with DNA, histone proteins serve as both a structural scaffold for DNA packaging into the nucleus and an epigenetic means for the regulation of gene expression. One such histone-based mechanism for ...
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PDF (4MB)
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(2017-06-30)Proteins are subject to a variety of stresses in biological organisms, including pressure and temperature, which are the easiest stresses to simulate by molecular dynamics simulations. The thesis will focus on discussing ...
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PDF (13MB)
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(1999)A tissue uptake model was developed to describe the fluorescein dermofluorometer signal in terms of the local blood flow and capillary permeability. The fluorescein signal is characterized by a wash-in time constant dependent ...
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PDF (7MB)
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(2002)In the second part of the thesis interactions of PAT-4, the C. elegans homologue of integrin-linked kinase (ILK), were investigated by FRET microscopy in living transgenic animals expressing CFP- and YFP-fusion proteins. ...
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PDF (12MB)
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(1992)Retinal physiology and metabolism, active areas of inquiry twenty years ago, have been relatively inactive recently. During the last twenty years, however, the development of nuclear magnetic resonance spectroscopy as a ...
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PDF (6MB)
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(2009)Statistical potentials offer a significant bioinformation-based alternative to physical potentials in protein structure prediction and design. As an introduction we survey the aspects and methods involved in the derivation ...
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PDF (3MB)
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(2002)Cytochrome c oxidase is a critical player in the process of cellular respiration, performing proton translocation coupled to the four-electron reduction of O2 to H2O. To accomplish this catalytic task, specific changes at ...
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PDF (8MB)
Now showing items 111-130 of 311