The vestibular-ocular reflex (VOR) is a plastic system found in vertebrates which produces eye rotations that compensate for head rotations. Simultaneous motion and vision are thus possible since the reflex keeps vision ...

In this work we characterize the sequence diversity of the heme-copper oxidoreductase superfamily by analyzing over 1100 microbial genomes (Bacteria and Archaea) and nine microbial environmental metagenomic datasets. Over ...

Many types of diseases including cancer and autism are associated with copy-number variations in the genome. Most of these variations could not be identified with existing sequencing and optical DNA mapping methods. We ...

Hydroperoxide is required to activate prostaglandin endoperoxide synthase (PES) cyclooxygenase by formation of an enzyme-radical species (derived from a PES peroxidase intermediate), and is generated by the cyclooxygenase ...

Melanins are complex, incompletely understood polymeric pigments which uniquely contain a stable population of organic free radicals amenable to study by electron paramagnetic resonance (EPR, or equivalently, electron spin ...

The cytochrome bc1 complex and its family members play a central role in biological energy transduction across all domains of life, oxidizing QH2 in a bifurcated reaction which generates a proton-motive force used for ATP ...

Proteins are subject to a variety of stresses in biological organisms, including pressure and temperature, which are the easiest stresses to simulate by molecular dynamics simulations. The thesis will focus on discussing ...

A tissue uptake model was developed to describe the fluorescein dermofluorometer signal in terms of the local blood flow and capillary permeability. The fluorescein signal is characterized by a wash-in time constant dependent ...

Retinal physiology and metabolism, active areas of inquiry twenty years ago, have been relatively inactive recently. During the last twenty years, however, the development of nuclear magnetic resonance spectroscopy as a ...

Cytochrome c oxidase is a critical player in the process of cellular respiration, performing proton translocation coupled to the four-electron reduction of O2 to H2O. To accomplish this catalytic task, specific changes at ...