“Head-to-head” terpene synthases catalyze the first committed steps in sterol and carotenoid biosynthesis: the condensation of two isoprenoid diphosphates to form cyclopropylcarbinyl diphosphates, followed by ring opening. ...

Chemotherapy with anticancer drugs is one of the main method of cancer treatment. The exploitation of the stereochemical interactions between anticancer drugs and DNA is of great importance for the ultimate clinical advances ...

Statistical potentials offer a significant bioinformation-based alternative to physical potentials in protein structure prediction and design. As an introduction we survey the aspects and methods involved in the derivation ...

The properties of ubiquinone and inhibitor binding to reaction centers (RCs) from the photosynthetic bacterium Rhodopseudomonas sphaeroides were studied. The charge recombination pathway between the primary electron donor, ...

In this thesis an attempt was made to take the water oxidizing complex apart in a controlled way and to reconstitute it to its functional form.