# Browse Dissertations - Biophysics and Computational Biology by Title

• (1995)
There has been a growing interest, in recent years, in the measurement of diffusion of water and metabolites in living systems by magnetic resonance (MR) techniques. Knowledge of the diffusion coefficients of the molecules ...

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• (1991)
The multicellular spheroid embodies many of the physiological and anatomical characteristics of in vivo tumors and provides an appropriate context for investigating the phenomenon of reoxygenation and the interplay of local ...

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• (1993)
A mathematical model has been developed to investigate the time course of ion and water transport across airway epithelia. Model variables were intracellular and apical concentrations of sodium, potassium, chloride; apical, ...

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• (2014-01-16)
Living cells have evolved specialized transport proteins called membrane transporters and channels that catalyze exchange of materials across the cell membrane. Membrane trans- porters couple the active transport of their ...

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• (2014-09-16)
Isoprenoids (or terpenes) are a large class of compounds with great physiological importance in all kingdoms of life. The research in this work explored the mechanism and inhibition of several enzymes in two important ...

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• (2012-06-27)
The methylerythritol phosphate pathway (also known as the non-mevalonate pathway) of isoprenoid biosynthesis is potentially an important anti-bacterial and anti-malarial drug target. However, the catalytic mechanisms of ...

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• (1974)

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• (2013-08-22)
ATP-binding cassette (ABC) transporters are a superfamily of primary membrane transporters that are abundant yet highly diverse in structures and functions. These proteins power the active transport of a large variety of ...

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• (1988)
The use of nitroxide spin labels in complex biological systems as biophysical tools to study molecular dynamics of membranes and cells and as contrast or imaging agents for NMR or ESR imaging and in vivo spectroscopy has ...

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• (2014-05-30)
Metalloproteins, proteins with metal ion cofactors, are estimated to make up more than a third of total proteome. They involve in key biological processes such as photosynthesis, respiration, and nitrogen fixation. The ...

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• (1983)
To understand the mechanism of rapid (time constants of 1-3 sec) buffering of intracellular calcium in molluscan cell bodies, a diffusion-reaction model was developed. The model took into account the binding reactions of ...

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• (2013-02-03)
Gene regulatory networks control gene expression during various biological processes, including two sets with similarity: differentiation processes of embryonic stem (ES) cells and embryo development processes. This thesis ...

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• (1996)
Properties of phospholipid membrane bilayers and of proteins associating and functioning in the membrane bilayer or at the membrane-water interface are studied by combining molecular dynamics simulations, free energy ...

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• (1991)
The Rieske iron-sulfur subunit of the cytochrome bc$\sb{1}$ complex of Rhodobacter sphaeroides assembles in the E. coli and R. sphaerodies membranes with its iron-sulfur cluster intact, in the absence of the cytochrome ...

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• (1990)
The ubiquinol:cytochrome c$\sb2$ oxidoreductase ($bc\sb1$ complex) is a central component of the mitochondrial respiratory chain as well as the respiratory and photosynthetic system of many prokaryotes. The fact that the ...

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• (2014-05-30)
Membrane transporters are specialized molecular machinery for selective, regulable, efficient, and more importantly, active transport of diverse chemical species, e.g., nutrients, reaction precursors and products, and ...

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• (2013-08-22)
Transport channels and pores are of fundamental importance for translocation of molecules across the otherwise-impermeable biological membrane. As a conduit for the passage of material, specific membrane channels must ...

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• (2008)
The thesis is consisted of three different sections independent of each other. The first part involves the frequency domain fluorescence lifetime imaging microscopy (FLIM) and an improvement of FLIM setup to decrease the ...

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• (2008)
Recent progress in solid-state NMR techniques presents unique opportunities to study the structure and dynamics of membrane proteins by using uniformly or extensively isotopically labeled samples. In this work, we first ...

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• (2008)
Macromolecular complexes carry out cellular processes that span many different length and time scales. Central to their function are both large-scale conformational changes, and atomic-atomic scale events. Molecular dynamics ...

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